Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469745 | 0.84 | ABL1 (0.51) | FGFR2FLT3ULK1MAPKAPK5EGFR | |
| SCHEMBL3470478 | 0.83 | MAPKAPK5 (0.43) | FGFR2FLT3MAPKAPK5EGFRSYK | |
| SCHEMBL14537044 | 0.81 | AURKA (0.45) | FGFR2FLT3MAPKAPK5EGFRSYK | |
| SCHEMBL8241606 | 0.81 | AURKA (0.58) | FGFR2FLT3MAPKAPK5EGFRSYK | |
| SCHEMBL11939505 | 0.80 | FLT1 (0.47) | FGFR2FLT3ULK1MAPKAPK5EGFR | |
| SCHEMBL1674087 | 0.79 | MAPKAPK5 (0.60) | FGFR2FLT3MAPKAPK5EGFRSYK | |
| SCHEMBL3470208 | 0.78 | FGFR2 (0.40) | FGFR2FLT3MAPKAPK5EGFRSYK | |
| SCHEMBL3469690 | 0.77 | PRKD1 (0.44) | FGFR2FLT3EPHX2ULK1MAPKAPK5 | |
| SCHEMBL3471097 | 0.77 | PIP4K2A (0.44) | MAPKAPK5SYKPTK6AURKAAURKB | |
| SCHEMBL2401175 | 0.76 | MAPKAPK5 (0.60) | FGFR2FLT3MAPKAPK5SYKTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |