⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29872697 | 0.71 | — | — | |
| SCHEMBL4501824 | 0.70 | — | — | |
| SCHEMBL4502639 | 0.64 | PARP1 (0.31) | — | |
| SCHEMBL4892208 | 0.60 | PARP1 (0.40) | — | |
| SCHEMBL5652264 | 0.59 | — | — | |
| SCHEMBL18440765 | 0.59 | ALDH1A1 (0.36) | — | |
| SCHEMBL2405951 | 0.59 | TRPA1 (0.32) | — | |
| SCHEMBL2405953 | 0.59 | TRPA1 (0.32) | — | |
| SCHEMBL4908709 | 0.57 | P2RX4 (0.31) | — | |
| SCHEMBL11667029 | 0.57 | LMNA (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1998782-A2 | METHODS FOR MODULATING BLADDER FUNCTION | Wyeth a Corporation of the State of Delaware (US) | 2008-12-10 | — | — | EP | claimed |
| EP-1998780-A2 | NEW THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | Wyeth a Corporation of the State of Delaware (US) | 2008-12-10 | — | — | EP | claimed |
| EP-1998773-A2 | NEW THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF DEPRESSION | Wyeth a Corporation of the State of Delaware (US) | 2008-12-10 | — | — | EP | claimed |
| EP-1998781-A2 | TREATMENT OF PAIN | Wyeth a Corporation of the State of Delaware (US) | 2008-12-10 | — | — | EP | claimed |
| WO-2007112014-A2 | NEW THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2007-10-04 | — | — | WO | claimed |
| WO-2007112073-A2 | METHODS FOR MODULATING BLADDER FUNCTION | WYETH (US) | 2007-10-04 | — | — | WO | claimed |
| WO-2007112000-A2 | TREATMENT OF PAIN | WYETH (US) | 2007-10-04 | — | — | WO | claimed |
| WO-2007111983-A2 | NEW THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | WYETH (US) | 2007-10-04 | — | — | WO | claimed |
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | claimed |
| US-20020119967-A1 | Pharmaceutical composition for preventing or treating a disease associated with an excess of IL-12-production | WARNER-LAMBERT COMPANY | 2002-08-29 | — | — | US | claimed |
| EP-1199074-A1 | Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production | WARNER-LAMBERT COMPANY (US) | 2002-04-24 | — | — | EP | claimed |
| US-20110294792-A1 | PURINE DERIVATIVES AS KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-12-01 | — | — | US | disclosed |
| US-20100086921-A1 | GENETIC SUSCEPTIBILITY VARIANTS OF TYPE 2 DIABETES MELLITUS | SAGA INVESTMENTS LLC | 2010-04-08 | — | — | US | disclosed |
| EP-2015749-A2 | METHODS FOR TREATING COGNITIVE AND OTHER DISORDERS | Wyeth (US) | 2009-01-21 | — | — | EP | disclosed |
| EP-1998781-A2 | TREATMENT OF PAIN | Wyeth a Corporation of the State of Delaware (US) | 2008-12-10 | — | — | EP | disclosed |
| EP-0828742-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | JOUVEINAL INST RECH (FR) | 2001-12-19 | — | — | EP | disclosed |
| EP-1161950-A1 | Use of diazepinoindoles for the treatment of chronic obstructive pulmonary disease | WARNER-LAMBERT COMPANY (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1161949-A1 | Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease | WARNER-LAMBERT COMPANY (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1132390-A2 | Diazepinoindoles as phophodiesterase inhibitors | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 2001-09-12 | — | — | EP | disclosed |
| US-5972927-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATORY MEDICINAL PRODUCTS, TREATMENT OF ASTHMA | JOUVEINAL (FR) | 1999-10-26 | — | — | US | disclosed |