Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 4/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19305561 | 0.69 | PARP1 (0.50) | PARP1NISCHHTR3A | |
| SCHEMBL3125224 | 0.67 | PARP1 (0.37) | PARP1NISCH | |
| SCHEMBL64500 | 0.64 | PARP1 (0.45) | PARP1HTR3AADRA2AADRA2BADRA2C | |
| SCHEMBL11883118 | 0.63 | ALKBH5 (0.38) | — | |
| SCHEMBL31635833 | 0.63 | PARP1 (0.34) | PARP1NISCH | |
| SCHEMBL17553824 | 0.62 | PARP1 (0.40) | PARP1NISCHHTR3A | |
| SCHEMBL9124525 | 0.62 | — | — | |
| SCHEMBL1395813 | 0.62 | MCL1 (0.44) | PARP1HTR3A | |
| SCHEMBL30955312 | 0.62 | MCL1 (0.44) | PARP1HTR3A | |
| SCHEMBL17262015 | 0.61 | PARP1 (0.41) | PARP1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351839-B2 | Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives | WYETH (US) | 2008-04-01 | — | — | US | disclosed |
| US-20080009480-A1 | CYCLOPENTA[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES | WYETH (US) | 2008-01-10 | — | — | US | disclosed |
| US-7271163-B2 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | WYETH (US) | 2007-09-18 | — | — | US | disclosed |
| US-20070066676-A1 | Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives | WYETH (US) | 2007-03-22 | — | — | US | disclosed |
| US-7141563-B2 | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives | WYETH (US) | 2006-11-28 | — | — | US | disclosed |
| US-6916922-B2 | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives | WYETH (US) | 2005-07-12 | — | — | US | disclosed |
| US-20050004101-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | WYETH (US) | 2005-01-06 | — | — | US | disclosed |
| EP-1330457-B1 | CYCLOPENTA[B][1,4] DIAZEPINO[6,7,1-HI]INDOLES AS 5HT2C ANTAGONISTS | WYETH CORP (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6777407-B2 | 7BH-CYCLOPENTA(B)(1,4)DIAZEPINO(6, 7, 1-HI)INDOLE OR A SALT, USEFUL FOR TREATMENT OF SCHIZOPHRENIA, OBSESSIVE COMPULSIVE DISORDER, DEPRESSION, ANXIETY, PANIC DISORDER, OBESITY OR EPILEPSY | WYETH | 2004-08-17 | — | — | US | disclosed |
| EP-1330457-A2 | CYCLOPENTA[B][1,4] DIAZEPINO[6,7,1-HI]INDOLES AS 5HT2C ANTAGONISTS | Wyeth (US) | 2003-07-30 | — | — | EP | disclosed |
| US-20020107242-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-08-08 | — | — | US | disclosed |
| US-6414144-B1 | SUCH AS (2S)-(REL-7BR,10AR)-2-METHYL-1,2,3,4,8,9,10,10A-OCTAHYDRO-7BH -CYCLOPENTA(B)(1,4)DIAZEPINO(6,7,1-HI)INDOLE; FOR TREATMENT OF OBESITY | WYETH | 2002-07-02 | — | — | US | disclosed |
| WO-2002042304-A2 | CYCLOPENTA[B][1,4] DIAZEPINO[6,7,1-HI]INDOLES AS 5HT2C ANTAGONISTS | WYETH (US) | 2002-05-30 | — | — | WO | disclosed |
| US-20020058689-A1 | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi]indole derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-05-16 | — | — | US | disclosed |
| US-20020055630-A1 | Such as (2S)-(rel-7bR,10aR)-2-Methyl-1,2,3,4,8,9,10,10a-octahydro-7bH -Cyclopenta(b)(1,4)Diazepino(6,7,1-hi)indole; for treatment of obesity | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-09 | — | — | US | disclosed |
| US-20020055504-A1 | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [b] [1,4] diazepino- [6,7,1-hi] indole derivatives | WYETH | 2002-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107242-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | CNR1, HCRTR1, HTR3C | PARP1 1209/4885NISCH 1048/4885HTR3A 13/4885 |
| US-20020058689-A1 | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi]indole derivatives | HRH3, HTR1A, HTR7 | PARP1 730/4885NISCH 158/4885HTR3A 22/4885 |
| US-20070066676-A1 | Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives | HRH4, HRH3, AHR | PARP1 2107/4885NISCH 121/4885HTR3A 11/4885 |
| US-20020055504-A1 | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [b] [1,4] diazepino- [6,7,1-hi] indole derivatives | CYP8B1, HTR2B, HTR1A | PARP1 1285/4885NISCH 204/4885HTR3A 11/4885 |
| US-20050004101-A1 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives | CNR1, HCRTR1, HTR3C | PARP1 1515/4885NISCH 751/4885HTR3A 14/4885 |
| US-20020055630-A1 | Such as (2S)-(rel-7bR,10aR)-2-Methyl-1,2,3,4,8,9,10,10a-octahydro-7bH -Cyclopenta(b)(1,4)Diazepino(6,7,1-hi)indole; for treatment of obesity | REL, HTR3B, HTR1B | PARP1 2130/4885NISCH 848/4885HTR3A 11/4885 |
| US-20080009480-A1 | CYCLOPENTA[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES | CNR1, HCRTR1, HTR3C | PARP1 1515/4885NISCH 751/4885HTR3A 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.