Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 5/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209740 | 0.78 | MGLL (0.44) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL4418973 | 0.77 | GABBR2 (0.35) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL19603733 | 0.76 | MGLL (0.37) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL3482194 | 0.76 | MGLL (0.37) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL8095583 | 0.76 | MGLL (0.37) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL24574686 | 0.74 | ALDH1A1 (0.36) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL5081930 | 0.74 | MGLL (0.36) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL8168349 | 0.74 | MGLL (0.46) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL1535503 | 0.74 | GAA (0.42) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL17924935 | 0.73 | MGLL (0.34) | MGLLALDH1A1LMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167083-A2 | NOVEL 1- HETEROARYL-3-AZABICYCLOÝ3.1.0¨HEXANES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | DOV Pharmaceutical, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008153937-A2 | NOVEL 1- HETEROARYL-3-AZABICYCLO[3.1.0]HEXANES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | DOV PHARMACEUTICAL, INC. (US) | 2008-12-18 | — | — | WO | disclosed |