Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418973 | 0.82 | GABBR2 (0.35) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL24574686 | 0.79 | ALDH1A1 (0.36) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL209740 | 0.78 | MGLL (0.44) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL19598997 | 0.77 | MGLL (0.34) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL3482194 | 0.76 | MGLL (0.37) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL8095583 | 0.76 | MGLL (0.37) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL3470187 | 0.76 | MGLL (0.37) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL28709416 | 0.76 | AOC3 (0.35) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL5081930 | 0.74 | MGLL (0.36) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL1535503 | 0.74 | GAA (0.42) | MGLLALDH1A1LMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11793880-B2 | Conjugates of quaternized tubulysin compounds | SEAGEN INC. (US) | 2023-10-24 | — | — | US | disclosed |
| WO-2021055865-A1 | SELECTIVE DRUG RELEASE FROM INTERNALIZED CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS | SEAGEN INC. (US) | 2021-03-25 | — | — | WO | disclosed |
| US-20170326247-A1 | ANTIBODY-DRUG CONJUGATES OF TUBULYSIN ANALOGS WITH ENHANCED STABILITY | BRISTOL-MYERS SQUIBB COMPANY | 2017-11-16 | — | — | US | disclosed |
| WO-2017196598-A1 | ANTIBODY-DRUG CONJUGATES OF TUBULYSIN ANALOGS WITH ENHANCED STABILITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11793880-B2 | Conjugates of quaternized tubulysin compounds | LCK, UACA, TEKT1 | MGLL 4657/4885ALDH1A1 4270/4885LMNA 2991/4885 |
| US-20170326247-A1 | ANTIBODY-DRUG CONJUGATES OF TUBULYSIN ANALOGS WITH ENHANCED STABILITY | NGLY1, TEK, MME | MGLL 3847/4885ALDH1A1 3890/4885LMNA 3835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.