Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ULK1 | O75385 | 2/20 | 0.44 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469679 | 0.89 | PRKD1 (0.40) | SYKEGFRULK1PRKD1ERBB2 | |
| SCHEMBL3469690 | 0.85 | PRKD1 (0.44) | SYKEGFRULK1PRKD1PRKCQ | |
| SCHEMBL3470208 | 0.84 | FGFR2 (0.40) | SYKEGFRPRKD1FGFR2FLT3 | |
| SCHEMBL3469529 | 0.83 | PRKD1 (0.41) | SYKEGFRULK1PRKD1PRKCQ | |
| SCHEMBL11939505 | 0.79 | FLT1 (0.47) | SYKEGFRULK1PRKD1FGFR2 | |
| SCHEMBL3466521 | 0.79 | LMNA (0.41) | JAK2FGFR2FLT3FYN | |
| SCHEMBL8246878 | 0.78 | FYN (0.47) | EGFRJAK2ERBB2FLT3FYN | |
| SCHEMBL3470478 | 0.77 | MAPKAPK5 (0.43) | SYKEGFRPRKD1PRKCQPRKCD | |
| SCHEMBL3470499 | 0.77 | FYN (0.62) | EGFRJAK2ERBB2FYN | |
| SCHEMBL8241606 | 0.77 | AURKA (0.58) | SYKEGFRERBB2FGFR2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |