Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.44 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 6/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470478 | 0.84 | MAPKAPK5 (0.43) | MAPKAPK5AURKAFYNAURKBPTK6 | |
| SCHEMBL3469261 | 0.83 | FYN (0.49) | MAPKAPK5AURKACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3466931 | 0.81 | CYP1A2 (0.47) | MAPKAPK5AURKACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8241606 | 0.78 | AURKA (0.58) | MAPKAPK5AURKAAURKBPTK6SYK | |
| SCHEMBL3470208 | 0.77 | FGFR2 (0.40) | MAPKAPK5CYP1A2PTK6SYK | |
| SCHEMBL3468104 | 0.77 | FGFR2 (0.42) | MAPKAPK5AURKAAURKBPTK6TTK | |
| SCHEMBL3469690 | 0.77 | PRKD1 (0.44) | MAPKAPK5CYP1A2TTKSYK | |
| SCHEMBL14537044 | 0.77 | AURKA (0.45) | MAPKAPK5AURKAAURKBPTK6TTK | |
| SCHEMBL3466251 | 0.76 | TTK (0.52) | CYP1A2CYP3A4CYP2D6CLK4FYN | |
| SCHEMBL11939505 | 0.76 | FLT1 (0.47) | MAPKAPK5SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |