Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 7/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 6/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 8/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.37 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL345243 | 0.96 | NOS2 (0.44) | NOS2NOS3NOS1SLC1A2SLC1A3 | |
| Bromide SCHEMBL1199534 | 0.79 | CA1 (0.35) | KIF11 | |
| Bromide SCHEMBL1199537 | 0.79 | CA1 (0.35) | KIF11 | |
| Bromide SCHEMBL4412730 | 0.78 | SLC7A5 (0.43) | NOS2NOS3NOS1SLC1A2SLC1A3 | |
| Bromide SCHEMBL4412737 | 0.78 | SLC7A5 (0.43) | NOS2NOS3NOS1SLC1A2SLC1A3 | |
| SCHEMBL6877041 | 0.78 | AOC1 (0.43) | NOS2NOS3NOS1SLC1A2SLC1A3 | |
| SCHEMBL6877039 | 0.78 | AOC1 (0.43) | NOS2NOS3NOS1SLC1A2SLC1A3 | |
| SCHEMBL6877044 | 0.78 | AOC1 (0.43) | NOS2NOS3NOS1SLC1A2SLC1A3 | |
| SCHEMBL1200264 | 0.78 | NOS2 (0.60) | NOS2NOS3NOS1SLC1A2SLC1A3 | |
| SCHEMBL3213014 | 0.78 | NOS2 (0.60) | NOS2NOS3NOS1SLC1A2SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015933-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2012-01-19 | — | — | US | disclosed |
| US-8039480-B2 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2011-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015933-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | GRIN2A 3014/4885NOS2 184/4885NOS3 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.