Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.67 |
| ▸ | BCHE | P06276 | 9/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9055677 | 0.94 | HPGDS (0.60) | HPGDSBCHEPARP14SLC6A2SLC6A3 | |
| SCHEMBL9053846 | 0.91 | HPGDS (0.56) | HPGDSBCHEPARP14DRD3CYP2D6 | |
| SCHEMBL21504949 | 0.88 | HPGDS (0.53) | HPGDSBCHEPARP14SLC6A2SLC6A3 | |
| SCHEMBL21496196 | 0.80 | HPGDS (1.00) | HPGDSBCHEPARP14SLC6A2SLC6A3 | |
| SCHEMBL3910868 | 0.80 | HPGDS (0.43) | HPGDSSLC6A2SLC6A3CHRM2HTR1A | |
| SCHEMBL9053324 | 0.79 | P2RX7 (0.55) | SLC6A2SLC6A3CHRM2CHRM1ADRA1A | |
| SCHEMBL9031522 | 0.79 | HPGDS (0.54) | HPGDSBCHEPARP14DRD3KCNH2 | |
| SCHEMBL6620398 | 0.76 | CHRM2 (0.61) | HPGDSBCHEPARP14SLC6A2SLC6A3 | |
| SCHEMBL4029782 | 0.76 | CHRM2 (0.61) | HPGDSBCHEPARP14SLC6A2SLC6A3 | |
| SCHEMBL6617728 | 0.76 | BCHE (0.65) | HPGDSBCHEPARP14SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9750749-B2 | Methods of treating thyroid eye disease | UNIVERSITY OF ROCHESTER (US) | 2017-09-05 | — | — | US | claimed |
| US-7238718-B2 | Method for treating myolytic disease and method for screening antimyolytic agent | OSAKA BIOSCIENCE INSTITUTE (JP) | 2007-07-03 | — | — | US | claimed |
| US-20050272767-A1 | Method for treating myolytic disease and method for screening antimyolytic agent | OSAKA BIOSCIENCE INSTITUTE AND RIKEN (JP) | 2005-12-08 | — | — | US | claimed |
| US-20050255576-A1 | Three-dimensinal structure of prostaglandin d synthase and utilization thereof | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2005-11-17 | — | — | US | claimed |
| US-20050227984-A1 | Drugs for improving the prognosis of brain injury and a method of screening the same | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2005-10-13 | — | — | US | claimed |
| EP-1535629-A1 | DRUGS FOR IMPROVING THE PROGNOSIS OF BRAIN INJURY AND A METHOD OF SCREENING THE SAME | Japan Science and Technology Agency (JP) | 2005-06-01 | — | — | EP | claimed |
| US-20250195518-A1 | INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2025-06-19 | — | — | US | disclosed |
| WO-2025104233-A1 | INHIBITION OF PROSTAGLANDIN D2 RECEPTOR 1 AS MEANS FOR TREATING CANCER | VIB VZW (BE) | 2025-05-22 | — | — | WO | disclosed |
| WO-2025104229-A1 | HEMATOPOIETIC PROSTAGLANDIN SYNTHASE (HPGDS) INHIBITION FOR TREATING CANCER | VIB VZW (BE) | 2025-05-22 | — | — | WO | disclosed |
| WO-2025104238-A1 | INHIBITION OF PROSTAGLANDIN D2 RECEPTOR 2 AS MEANS FOR TREATING CANCER | VIB VZW (BE) | 2025-05-22 | — | — | WO | disclosed |
| EP-4488271-A1 | INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | Japan Tobacco Inc. (JP) | 2025-01-08 | — | — | EP | disclosed |
| CN-118765278-A | Indazole compounds and pharmaceutical uses thereof | 日本烟草产业株式会社 | 2024-10-11 | — | — | CN | disclosed |
| WO-2023163140-A1 | INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | 日本たばこ産業株式会社 | 2023-08-31 | — | — | WO | disclosed |
| EP-1598065-A2 | Drugs for improving prognosis of brain injury | Japan Science and Technology Agency (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-20050255576-A1 | Three-dimensinal structure of prostaglandin d synthase and utilization thereof | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2005-11-17 | — | — | US | disclosed |
| US-20050227984-A1 | Drugs for improving the prognosis of brain injury and a method of screening the same | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2005-10-13 | — | — | US | disclosed |
| US-20050222235-A1 | Drugs for improving the prognosis of brain injury and a method of screening the same | SHIONOGI & CO., LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
| EP-1535629-A1 | DRUGS FOR IMPROVING THE PROGNOSIS OF BRAIN INJURY AND A METHOD OF SCREENING THE SAME | Japan Science and Technology Agency (JP) | 2005-06-01 | — | — | EP | disclosed |
| EP-0706522-A1 | TETRAZOLE DERIVATIVES HAVING ANTIHISTAMINIC AND ANTIALLERGIC ACTIVITY | SUMITOMO METAL INDUSTRIES, LTD. (JP) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001350-A1 | TETRAZOLE DERIVATIVES HAVING ANTIHISTAMINIC AND ANTIALLERGIC ACTIVITY | SUMITOMO METAL INDUSTRIES, LTD. (JP) | 1995-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222235-A1 | Drugs for improving the prognosis of brain injury and a method of screening the same | HPGDS, PTGDR, PTGDR2 | HPGDS 1/4885BCHE 1306/4885PARP14 1866/4885 |
| US-20250195518-A1 | INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | HPGDS, PTGIS, HPGD | HPGDS 1/4885BCHE 1373/4885PARP14 1604/4885 |
| US-20050227984-A1 | Drugs for improving the prognosis of brain injury and a method of screening the same | HPGDS, PTGDR, PTGDR2 | HPGDS 1/4885BCHE 1306/4885PARP14 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.