Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | PRNP | P04156 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31272247 | 0.86 | PARP1 (0.56) | CHEK1CDK4SRCCCND1ALDH1A1 | |
| SCHEMBL9204198 | 0.86 | PARP1 (0.56) | CHEK1CDK4SRCCCND1ALDH1A1 | |
| SCHEMBL3472838 | 0.81 | CHEK1 (0.48) | CHEK1CDK4SRCCCND1ALDH1A1 | |
| SCHEMBL1286636 | 0.79 | PARP1 (0.56) | CHEK1CDK4SRCCCND1ALDH1A1 | |
| SCHEMBL30577447 | 0.79 | PARP1 (0.56) | CHEK1CDK4SRCCCND1ALDH1A1 | |
| SCHEMBL3473510 | 0.79 | CHEK1 (0.46) | CHEK1CDK4SRCCCND1ALDH1A1 | |
| SCHEMBL1848649 | 0.78 | PARP1 (0.53) | CDK4CCND1PARP1KDM4EGABRA1 | |
| SCHEMBL6826793 | 0.78 | PARP1 (0.50) | CHEK1CDK4SRCCCND1ALDH1A1 | |
| SCHEMBL17396507 | 0.78 | RXFP1 (0.55) | CHEK1ALDH1A1PARP1KDM4EHPGD | |
| SCHEMBL38652511 | 0.78 | PARP1 (0.50) | CHEK1CDK4SRCCCND1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193430-B2 | Methods for separating carbon nanotubes | THE UNIVERSITY OF CONNECTICUT (US) | 2012-06-05 | — | — | US | disclosed |
| US-20100044230-A1 | METHODS FOR SEPARATING CARBON NANOTUBES | UNIVERSITY OF CONNECTICUT (US) | 2010-02-25 | — | — | US | disclosed |
| WO-2008147852-A1 | KINESIN INHIBITORS | TAIGEN BIOTECHNOLOGY CO., LTD. (TW) | 2008-12-04 | — | — | WO | disclosed |
| US-20050187389-A1 | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases | AMBIT BIOSCIENCES CORPORATION | 2005-08-25 | — | — | US | disclosed |
| WO-2005067546-A2 | PYRROLOPYRIMIDINE DERIVATIVES AND ANALOGS AND THEIR USE IN THE TREATMENT AND PREVENTION OF DISEASES | AMBIT BIOSCIENCES CORPORATION (US) | 2005-07-28 | — | — | WO | disclosed |
| US-20050153989-A1 | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases | AMBIT BIOSCIENCES CORPORATION | 2005-07-14 | — | — | US | disclosed |
| WO-2004111052-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE (MDR) | XENOVA LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100044230-A1 | METHODS FOR SEPARATING CARBON NANOTUBES | FSCN1, TTPA, FLNB | CHEK1 2918/4885CDK4 3362/4885SRC 4289/4885 |
| US-20050187389-A1 | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases | PRKDC, PRKCA, PRKACA | CHEK1 210/4885CDK4 266/4885SRC 413/4885 |
| US-20050153989-A1 | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases | PRKDC, PRKCA, PRKACA | CHEK1 210/4885CDK4 266/4885SRC 413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.