Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | FBP1 | P09467 | 6/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 2/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950826 | 0.89 | KDM4E (0.59) | GAASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL19899736 | 0.86 | NPC1 (0.60) | GAASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL25248374 | 0.85 | IL6 (0.61) | GAASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14268619 | 0.85 | FBP1 (0.62) | GAASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL3814734 | 0.85 | KCNH2 (0.53) | GAAFBP1KCNH2MEN1KMT2A | |
| SCHEMBL12095337 | 0.82 | FBP1 (0.54) | GAAFBP1KCNH2MEN1KMT2A | |
| SCHEMBL29862435 | 0.81 | IL6 (0.72) | GAASMN1; SMN2ALDH1A1FBP1KCNH2 | |
| SCHEMBL12095512 | 0.81 | IL6 (0.72) | GAASMN1; SMN2ALDH1A1FBP1KCNH2 | |
| SCHEMBL3949035 | 0.81 | NPC1 (0.71) | GAASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13436713 | 0.81 | RAB9A (0.66) | GAASMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102834098-B | Benzheterocyclic derivatives for cancerous precaution and treatment or the purposes suppressing cancerometastasis | Medical life fusion research group (KR) | 2016-01-20 | — | — | CN | claimed |
| EP-2497471-B1 | USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS | SNU R&DB FOUNDATION (KR) | 2015-04-15 | — | — | EP | claimed |
| CN-102834098-A | Use of benzo-heterocycle derivatives for preventing and treating cancer or for inhibiting cancer metastasis | SNU R&DB FOUNDATION | 2012-12-19 | — | — | CN | claimed |
| US-20120283300-A1 | USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS | SNU R&DB FOUNDATION (KR) | 2012-11-08 | — | — | US | claimed |
| EP-2497471-A2 | USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS | SNU R&DB Foundation (KR) | 2012-09-12 | — | — | EP | claimed |
| EP-1034176-A1 | THIOPHENE-SULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-13 | — | — | EP | claimed |
| WO-1999028316-A1 | THIOPHENE-SULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | claimed |
| US-10130611-B2 | Use of benzo-heterocycle derivatives for preventing and treating cancer or for inhibiting cancer metastasis | MEDICINAL BIOCONVERGENCE RESEARCH CENTER (KR) | 2018-11-20 | — | — | US | disclosed |
| CN-102834098-B | Benzheterocyclic derivatives for cancerous precaution and treatment or the purposes suppressing cancerometastasis | Medical life fusion research group (KR) | 2016-01-20 | — | — | CN | disclosed |
| EP-2497471-B1 | USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS | SNU R&DB FOUNDATION (KR) | 2015-04-15 | — | — | EP | disclosed |
| CN-102834098-A | Use of benzo-heterocycle derivatives for preventing and treating cancer or for inhibiting cancer metastasis | SNU R&DB FOUNDATION | 2012-12-19 | — | — | CN | disclosed |
| US-20120283300-A1 | USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS | SNU R&DB FOUNDATION (KR) | 2012-11-08 | — | — | US | disclosed |
| US-20120283300-A1 | USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS | SNU R&DB FOUNDATION (KR) | 2012-11-08 | — | — | US | disclosed |
| EP-2497471-A2 | USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS | SNU R&DB Foundation (KR) | 2012-09-12 | — | — | EP | disclosed |
| WO-2010039186-A2 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039186-A2 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| EP-1034176-A1 | THIOPHENE-SULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-13 | — | — | EP | disclosed |
| WO-1999028316-A1 | THIOPHENE-SULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10130611-B2 | Use of benzo-heterocycle derivatives for preventing and treating cancer or for inhibiting cancer metastasis | MKI67, KISS1R, NPY1R | GAA 977/4885SMN1; SMN2 4448/4885NPC1 2356/4885 |
| US-20120283300-A1 | USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS | MKI67, KISS1R, NPY1R | GAA 977/4885SMN1; SMN2 4448/4885NPC1 2356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.