Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475610 | 0.85 | FAAH (0.40) | FAAHLMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL3476467 | 0.84 | PRKD3 (0.44) | LMNAHTTMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL3476466 | 0.84 | PRKD3 (0.44) | LMNAHTTMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL3478580 | 0.83 | HRH4 (0.39) | LMNAHTTMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL3476097 | 0.78 | MAPT (0.55) | LMNAMAPTSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL3124224 | 0.77 | MAPT (0.50) | LMNAHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13072518 | 0.75 | MAP4K4 (0.42) | FAAHMAPTSMO | |
| SCHEMBL3118831 | 0.75 | GRIA1 (0.42) | LMNAHTTMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL3765693 | 0.71 | LMNA (0.72) | FAAHLMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL15825263 | 0.70 | KCNH2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130934-A2 | 2-CYCLOAMINO-5-(PYRIDIN-4-YL)IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |