Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3478605 | 0.81 | GAA (0.53) | MAPTLMNAGAATHRBF2RL3 | |
| SCHEMBL14680409 | 0.78 | MAPT (0.71) | MAPTLMNAGAATHRB | |
| SCHEMBL3475609 | 0.78 | FAAH (0.41) | MAPTLMNAGAAALDH1A1MAPK1 | |
| SCHEMBL3475610 | 0.77 | FAAH (0.40) | MAPTLMNAGAAALDH1A1MAPK1 | |
| SCHEMBL3111060 | 0.77 | MAPT (0.46) | MAPTLMNAGAATHRBALDH1A1 | |
| SCHEMBL3765693 | 0.77 | LMNA (0.72) | MAPTLMNAGAAALDH1A1MAPK1 | |
| SCHEMBL3476467 | 0.74 | PRKD3 (0.44) | MAPTLMNAALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL3476466 | 0.74 | PRKD3 (0.44) | MAPTLMNAALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL13072855 | 0.73 | MAPT (0.51) | MAPTLMNAGAATHRBF2RL3 | |
| SCHEMBL20337993 | 0.73 | MAPT (0.58) | MAPTLMNAGAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130934-A2 | 2-CYCLOAMINO-5-(PYRIDIN-4-YL)IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |