Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | USP1 | O94782 | 1/20 | 0.30 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.30 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476441 | 0.79 | NPC1 (0.38) | ALDH1A1KDM4E | |
| SCHEMBL2783541 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4ENOS2HPGDTSHR | |
| SCHEMBL15282121 | 0.69 | ALDH1A1 (0.50) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL31158570 | 0.68 | GRM2 (0.42) | — | |
| SCHEMBL34460865 | 0.68 | GRM2 (0.42) | — | |
| SCHEMBL13256248 | 0.67 | ALDH1A1 (0.40) | ALDH1A1KDM4ECYP2A6CYP1A2SMN1; SMN2 | |
| SCHEMBL13415445 | 0.66 | — | — | |
| SCHEMBL8968728 | 0.66 | — | — | |
| SCHEMBL9255732 | 0.66 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2HPGDUSP1WDR48 | |
| SCHEMBL6718678 | 0.65 | ALDH1A1 (0.35) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659000-B2 | Tie layer material for such polymer pairs is prepared, preferably in the extruder, by melt reaction of one of the two polymers, a coupling agent reactive with both polymers and optionally a catalyst | BOSTON SCIENTIFIC SCIMED, INC. (US) | 2010-02-09 | — | — | US | disclosed |
| EP-1740378-B9 | ADHESION TECHNIQUE FOR INCOMPATIBLE POLYMERS USING MODIFIED POLYMER TIE LAYERS | BOSTON SCIENT LTD (BB) | 2008-08-06 | — | — | EP | disclosed |
| EP-1740378-B1 | ADHESION TECHNIQUE FOR INCOMPATIBLE POLYMERS USING MODIFIED POLYMER TIE LAYERS | BOSTON SCIENT LTD (BB) | 2008-04-23 | — | — | EP | disclosed |
| US-20050227087-A1 | Adhesion technique for incompatible polymers using modified polymer tie layers | SCIMED LIFE SYSTEMS, INC. (US) | 2005-10-13 | — | — | US | disclosed |