Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476376 | 0.79 | ALDH1A1 (0.41) | ALDH1A1KDM4E | |
| SCHEMBL13256248 | 0.77 | ALDH1A1 (0.40) | ALDH1A1KDM4E | |
| SCHEMBL2782902 | 0.77 | ALDH1A1 (0.42) | NPC1ALDH1A1NISCH | |
| SCHEMBL6718678 | 0.72 | ALDH1A1 (0.35) | ALDH1A1KDM4E | |
| SCHEMBL10521596 | 0.71 | NPC1 (0.45) | NPC1ALDH1A1 | |
| SCHEMBL9255732 | 0.70 | ALDH1A1 (0.40) | NPC1ALDH1A1NISCH | |
| SCHEMBL1338547 | 0.68 | NISCH (0.50) | NPC1ALDH1A1NISCH | |
| SCHEMBL10520201 | 0.67 | NPC1 (0.37) | NPC1ALDH1A1 | |
| SCHEMBL9322435 | 0.67 | NPC1 (0.50) | NPC1ALDH1A1NISCH | |
| SCHEMBL9319820 | 0.67 | SMN1; SMN2 (0.42) | NPC1ALDH1A1NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659000-B2 | Tie layer material for such polymer pairs is prepared, preferably in the extruder, by melt reaction of one of the two polymers, a coupling agent reactive with both polymers and optionally a catalyst | BOSTON SCIENTIFIC SCIMED, INC. (US) | 2010-02-09 | — | — | US | disclosed |
| EP-1740378-B9 | ADHESION TECHNIQUE FOR INCOMPATIBLE POLYMERS USING MODIFIED POLYMER TIE LAYERS | BOSTON SCIENT LTD (BB) | 2008-08-06 | — | — | EP | disclosed |
| EP-1740378-B1 | ADHESION TECHNIQUE FOR INCOMPATIBLE POLYMERS USING MODIFIED POLYMER TIE LAYERS | BOSTON SCIENT LTD (BB) | 2008-04-23 | — | — | EP | disclosed |
| EP-1740378-A1 | ADHESION TECHNIQUE FOR INCOMPATIBLE POLYMERS USING MODIFIED POLYMER TIE LAYERS | Boston Scientific Limited (BB) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005102689-A1 | ADHESION TECHNIQUE FOR INCOMPATIBLE POLYMERS USING MODIFIED POLYMER TIE LAYERS | BOSTON SCIENTIFIC LIMITED (BB) | 2005-11-03 | — | — | WO | disclosed |
| US-20050227087-A1 | Adhesion technique for incompatible polymers using modified polymer tie layers | SCIMED LIFE SYSTEMS, INC. (US) | 2005-10-13 | — | — | US | disclosed |