Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 8/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13436640 | 0.87 | FAAH (0.61) | FAAHPIK3CAHDAC6ELANEMAPT | |
| SCHEMBL3477307 | 0.80 | FAAH (0.66) | FAAHPIK3CAHDAC6ELANEMAPT | |
| SCHEMBL3475819 | 0.79 | FAAH (0.65) | FAAHPIK3CAHDAC6ELANERAB9A | |
| SCHEMBL3477409 | 0.79 | FAAH (0.71) | FAAHPIK3CAHDAC6ELANEMAPT | |
| SCHEMBL13436763 | 0.78 | FAAH (0.76) | FAAHPIK3CAHDAC6ELANEMAPT | |
| SCHEMBL3477428 | 0.78 | FAAH (0.64) | FAAHPIK3CAHDAC6DYRK1AELANE | |
| SCHEMBL3474618 | 0.77 | FAAH (0.62) | FAAHPIK3CAHDAC6ELANE | |
| SCHEMBL13436727 | 0.77 | FAAH (0.54) | FAAHPIK3CAHDAC6ELANE | |
| SCHEMBL3477976 | 0.77 | FAAH (0.54) | FAAHPIK3CAHDAC6ELANEMAPT | |
| SCHEMBL3477717 | 0.76 | HDAC6 (0.67) | FAAHPIK3CAHDAC6ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039186-A2 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039186-A2 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |