Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.62 |
| ▸ | CTSK | P43235 | 5/20 | 0.62 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273440 | 0.92 | CTSS (0.72) | CTSSCTSKCTSLCTSBMMP1 | |
| SCHEMBL5188769 | 0.92 | CTSS (0.72) | CTSSCTSKCTSLCTSBMMP1 | |
| SCHEMBL5188418 | 0.92 | CTSS (0.72) | CTSSCTSKCTSLCTSBMMP1 | |
| SCHEMBL3478075 | 0.85 | PTPRB (0.58) | CTSSCTSK | |
| SCHEMBL3477645 | 0.85 | CTSS (0.58) | CTSSCTSKCTSLCTSBMMP1 | |
| SCHEMBL13224680 | 0.85 | PTPRB (0.58) | CTSSCTSK | |
| SCHEMBL15910014 | 0.85 | KLK5 (0.55) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL28630396 | 0.84 | CTSS (0.72) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL22191069 | 0.83 | CTSS (0.67) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL22201737 | 0.83 | CTSS (0.67) | CTSSCTSKCTSLCTSBREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7769575-B2 | Three dimensional coordinates of HPTPbeta | Warner Chilcott, LLC (US) | 2010-08-03 | — | — | US | disclosed |
| US-20100030487-A1 | THREE DIMENSIONAL COORDINATES OF HPTPbeta | Aerpio Pharmaceuticals, Inc. | 2010-02-04 | — | — | US | disclosed |
| US-20040077065-A1 | Three dimensional coordinates of HPTPbeta | THE PROCTER & GAMBLE COMPANY | 2004-04-22 | — | — | US | disclosed |