Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.58 |
| ▸ | CTSK | P43235 | 5/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6808320 | 0.94 | PPARG (0.57) | CTSSCTSKPPARGPPARAMMP1 | |
| SCHEMBL6808317 | 0.94 | PPARG (0.57) | CTSSCTSKPPARGPPARAMMP1 | |
| SCHEMBL6803377 | 0.91 | CTSS (0.57) | CTSSCTSKPPARGPPARACTSL | |
| SCHEMBL6803380 | 0.91 | CTSS (0.57) | CTSSCTSKPPARGPPARACTSL | |
| SCHEMBL5188418 | 0.88 | CTSS (0.72) | CTSSCTSKPPARAMMP1CTSL | |
| SCHEMBL7273440 | 0.88 | CTSS (0.72) | CTSSCTSKPPARAMMP1CTSL | |
| SCHEMBL5188769 | 0.88 | CTSS (0.72) | CTSSCTSKPPARAMMP1CTSL | |
| SCHEMBL14552051 | 0.86 | PPARG (0.54) | CTSSCTSKPPARGPPARACTSL | |
| SCHEMBL31213493 | 0.85 | CTSS (0.54) | CTSSCTSKPPARGPPARACTSL | |
| SCHEMBL3477448 | 0.85 | CTSS (0.62) | CTSSCTSKMMP1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7769575-B2 | Three dimensional coordinates of HPTPbeta | Warner Chilcott, LLC (US) | 2010-08-03 | — | — | US | disclosed |
| US-20100030487-A1 | THREE DIMENSIONAL COORDINATES OF HPTPbeta | Aerpio Pharmaceuticals, Inc. | 2010-02-04 | — | — | US | disclosed |