Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3478461 | 0.84 | RAB9A (0.40) | HSP90AA1RAB9AMEN1KMT2ATUBB4A | |
| SCHEMBL5229048 | 0.78 | LMNA (0.50) | HSP90AA1LMNACLK1RAB9AMEN1 | |
| SCHEMBL826722 | 0.78 | CYP2A6 (0.52) | BACE1CLK1RAB9AMEN1KMT2A | |
| SCHEMBL4580171 | 0.78 | BACE1 (0.67) | BACE1CLK1CA2CYP2A6DYRK1A | |
| SCHEMBL1744396 | 0.75 | HSP90AA1 (0.52) | HSP90AA1LMNACLK1RAB9AMEN1 | |
| SCHEMBL14761179 | 0.74 | HSP90AA1 (0.44) | HSP90AA1LMNABACE1CLK1RAB9A | |
| SCHEMBL5163126 | 0.74 | LMNA (0.50) | HSP90AA1LMNACLK1RAB9AMEN1 | |
| SCHEMBL3125932 | 0.74 | HSP90AA1 (0.55) | HSP90AA1LMNABACE1RAB9AMEN1 | |
| SCHEMBL21326404 | 0.72 | HSP90AA1 (0.53) | HSP90AA1LMNABACE1RAB9AMEN1 | |
| SCHEMBL147625 | 0.72 | TUBB4A (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167083-A2 | NOVEL 1- HETEROARYL-3-AZABICYCLOÝ3.1.0¨HEXANES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | DOV Pharmaceutical, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008153937-A2 | NOVEL 1- HETEROARYL-3-AZABICYCLO[3.1.0]HEXANES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | DOV PHARMACEUTICAL, INC. (US) | 2008-12-18 | — | — | WO | disclosed |