SCHEMBL3481432

SCHEMBL3481432

Nc1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
USP2 O75604 3/20 1.00
L3MBTL1 Q9Y468 1/20 1.00
MEN1 O00255 2/20 0.70
POLB P06746 2/20 0.70
KMT2A Q03164 2/20 0.70
ALPL P05186 1/20 0.70
ALPI P09923 1/20 0.70
ALPG P10696 1/20 0.70
ATM Q13315 1/20 0.62
PLEC Q15149 1/20 0.62
CA9 Q16790 16/20 0.61
CA1 P00915 14/20 0.61
CA2 P00918 14/20 0.61
CA12 O43570 6/20 0.58
DNASE1L3 Q13609 1/20 0.56
PRMT1 Q99873 1/20 0.56
CA14 Q9ULX7 2/20 0.55
CA7 P43166 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30023431 1.00 USP2 (1.00) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL13384808 0.92 USP2 (0.85) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL25829608 0.89 USP2 (0.80) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL17920161 0.88 USP2 (0.78) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL1437042 0.87 USP2 (0.78) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL20254033 0.87 USP2 (0.77) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL15496802 0.87 USP2 (0.77) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL12463125 0.87 USP2 (0.77) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL10098714 0.86 USP2 (0.76) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL7970059 0.86 USP2 (0.76) USP2L3MBTL1MEN1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230040324-A1 AMINOACRIDINE AND AMINOPYRENE DYES AND THEIR USE AS FLUORESCENT TAGS, IN PARTICULAR FOR CARBOHYDRATE ANALYSIS MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V. (DE) 2023-02-09 US disclosed
US-11254786-B2 Multifunctional degradable nanoparticles with control over size and functionalities VANDERBILT UNIVERSITY (US) 2022-02-22 US disclosed
US-20220000996-A1 CHIMERIC ANTIGEN RECEPTOR-EXPRESSING T CELLS AS ANTI-CANCER THERAPEUTICS PURDUE RESEARCH FOUNDATION 2022-01-06 US disclosed
WO-2021110280-A1 AMINOACRIDINE AND AMINOPYRENE DYES AND THEIR USE AS FLUORESCENT TAGS, IN PARTICULAR FOR CARBOHYDRATE ANALYSIS Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. (DE) 2021-06-10 WO disclosed
US-20210041465-A1 FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE Life Technologies Corporation 2021-02-11 US disclosed
US-10845373-B2 Fluorogenic pH sensitive dyes and their method of use Life Technologies Corporation (US) 2020-11-24 US disclosed
WO-2020151804-A1 SULFONATED 2(7)-AMINOACRIDONE AND 1-AMINOPYRENE DYES AND THEIR USE AS FLUORESCENT TAGS, IN PARTICULAR FOR CARBOHYDRATE ANALYSIS Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. (DE) 2020-07-30 WO disclosed
EP-2972227-B1 DIGITALLY ENHANCED MICROSCOPY FOR MULTIPLEXED HISTOLOGY VENTANA MED SYST INC (US) 2020-05-06 EP disclosed
US-10442890-B2 Multifunctional degradable nanoparticles with control over size and functionalities VANDERBILT UNIVERSITY (US) 2019-10-15 US disclosed
EP-2569434-B1 COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA AND RELATED DISORDERS DANA FARBER CANCER INST INC (US) 2019-09-04 EP disclosed
US-20080138291-A1 Sulfonamide Derivatives Having Carbonic Anhydrase Inhibiting Activity and their Use as Therapeutic and Diagnostic Agents UNION LIFE SCIENCES LTD. (GB) 2008-06-12 US disclosed
US-7279585-B2 Lipophilic electrophoretic probes MONOGRAM BIOSCIENCES, INC. (US) 2007-10-09 US disclosed
US-20070221884-A1 Liminescent Silicon Oxide Flakes CIBA SPECIALTY CHEMICALS CORP. 2007-09-27 US disclosed
US-20070221884-A1 Liminescent Silicon Oxide Flakes CIBA SPECIALTY CHEMICALS CORP. 2007-09-27 US disclosed
US-20070184513-A1 Substrates for beta-lactamase and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-08-09 US disclosed
WO-2007076379-A2 4,7-DIHYDROTHIENO[2,3-B]PYRIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS GILEAD COLORADO, INC. (US) 2007-07-05 WO disclosed
WO-2007073555-A1 USE OF 4, 7-DIHYDROTHIENO [2, 3-B] PYRIDINE COMPOUNDS IN THE TREATMENT OF CARDIOVASCULAR DISEASES GILEAD COLORADO, INC. (US) 2007-06-28 WO disclosed
WO-2007029122-A2 FLUORESCEIN-BASED COMPOUNDS AND THEIR USE FOR PEPTIDE SYNTHESIS COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 2007-03-15 WO disclosed
US-7157575-B2 Substrates for β-lactamase and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-01-02 US disclosed
US-7157575-B2 Substrates for β-lactamase and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11254786-B2 Multifunctional degradable nanoparticles with control over size and functionalities DSTN, PARN, CTSA USP2 202/4885L3MBTL1 2435/4885MEN1 1242/4885
US-20080138291-A1 Sulfonamide Derivatives Having Carbonic Anhydrase Inhibiting Activity and their Use as Therapeutic and Diagnostic Agents CA9, CA4, CA2 USP2 2200/4885L3MBTL1 4660/4885MEN1 2646/4885
US-10442890-B2 Multifunctional degradable nanoparticles with control over size and functionalities DSTN, PARN, CTSA USP2 202/4885L3MBTL1 2435/4885MEN1 1242/4885
US-10845373-B2 Fluorogenic pH sensitive dyes and their method of use SLC11A2, MAN2B1, CD47 USP2 3728/4885L3MBTL1 4356/4885MEN1 1603/4885
US-20220000996-A1 CHIMERIC ANTIGEN RECEPTOR-EXPRESSING T CELLS AS ANTI-CANCER THERAPEUTICS CD4, CD2, CD47 USP2 3131/4885L3MBTL1 413/4885MEN1 2930/4885
US-20210041465-A1 FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE SLC11A2, MAN2B1, CD47 USP2 3728/4885L3MBTL1 4356/4885MEN1 1603/4885
US-20070184513-A1 Substrates for beta-lactamase and uses thereof CMBL, DBH, NCEH1 USP2 697/4885L3MBTL1 89/4885MEN1 3743/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.