Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 16/20 | 0.75 |
| ▸ | PRKAB1 | Q9Y478 | 16/20 | 0.75 |
| ▸ | PRKAA2 | P54646 | 12/20 | 0.75 |
| ▸ | PRKAA1 | Q13131 | 11/20 | 0.66 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.66 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.66 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.66 |
| ▸ | TFDP2 | Q14188 | 1/20 | 0.66 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3481456 | 0.93 | PRKAG1 (0.78) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL3481416 | 0.89 | PRKAG1 (0.65) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL3481453 | 0.86 | PRKAG1 (0.96) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL13403023 | 0.85 | PRKAG1 (0.85) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL3481008 | 0.85 | PRKAB1 (0.87) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL29659650 | 0.85 | PRKAG1 (0.87) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| Ammonia Solution, Strong SCHEMBL3481326 | 0.85 | PRKAG1 (0.84) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| Ammonia Solution, Strong SCHEMBL3481330 | 0.85 | PRKAG1 (0.84) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL3481210 | 0.85 | PRKAG1 (0.87) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL3481220 | 0.84 | PRKAG1 (0.81) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394969-B2 | Cyclic benzimidazole derivatives useful as anti-diabetic agents | MERCK SHARP & DOHME CORP. (US) | 2013-03-12 | — | — | US | disclosed |
| US-8394969-B2 | Cyclic benzimidazole derivatives useful as anti-diabetic agents | MERCK SHARP & DOHME CORP. (US) | 2013-03-12 | — | — | US | disclosed |
| US-8394969-B2 | Cyclic benzimidazole derivatives useful as anti-diabetic agents | MERCK SHARP & DOHME CORP. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20100081643-A1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME LLC | 2010-04-01 | — | — | US | disclosed |
| US-20100081643-A1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME LLC | 2010-04-01 | — | — | US | disclosed |
| US-20100081643-A1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME LLC | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081643-A1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | PRKAG2, PRKAG1, PRKAB2 | PRKAG1 2/4885PRKAB1 5/4885PRKAA2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.