Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.72 |
| ▸ | DRD2 | P14416 | 4/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | HTR6 | P50406 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828404 | 0.84 | DRD2 (0.59) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL27351820 | 0.84 | DRD2 (0.58) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL4520581 | 0.83 | KMT2A (0.61) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL9612238 | 0.83 | DRD2 (0.62) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL3210395 | 0.83 | DRD2 (0.60) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL23536279 | 0.81 | HTR1A (0.58) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL9155290 | 0.81 | HTR1A (0.58) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL29932017 | 0.81 | HTR1A (0.58) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL3210388 | 0.81 | DRD2 (0.59) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL18118448 | 0.80 | DRD2 (0.58) | DRD2DRD4DRD3HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150550-A1 | NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK Holdings Co., Ltd. (KR) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008140197-A1 | NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK HOLDINGS CO., LTD. (KR) | 2008-11-20 | — | — | WO | disclosed |