SCHEMBL3482352

SCHEMBL3482352

O=C1C=CC(=O)N1C(F)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 5/20 0.35
GSK3A P49840 1/20 0.35
GSK3B P49841 1/20 0.35
FAAH O00519 2/20 0.32
GMNN O75496 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
THPO P40225 1/20 0.31
BLM P54132 1/20 0.31
PMP22 Q01453 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21419589 0.78 MGLL (0.35) MGLLGSK3AGSK3BFAAHGMNN
SCHEMBL5889438 0.78 MGLL (0.35) MGLLGSK3AGSK3BFAAHGMNN
SCHEMBL3482921 0.77 MGLL (0.38) MGLLGSK3AGSK3BFAAHGMNN
SCHEMBL9852613 0.76 MGLL (0.33) MGLLGSK3AGSK3BFAAH
SCHEMBL9578152 0.72 MGLL (0.35) MGLLGSK3AGSK3BFAAHGMNN
SCHEMBL9578119 0.72 MGLL (0.35) MGLLGSK3AGSK3BFAAHGMNN
SCHEMBL1264092 0.72 LMNA (0.31) MGLLGSK3AGSK3BLMNA
SCHEMBL29181143 0.70 MGLL (0.35) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL3482453 0.70 TLR9 (0.30)
SCHEMBL9578159 0.70 MGLL (0.33) MGLLGSK3AGSK3BFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7031589-B2 Material for attenuating light signals with low reflectance in a fiber optic network FURUKAWA ELECTRIC NORTH AMERICA (US) 2006-04-18 US claimed
US-20040264908-A1 Material for attenuating light signals with low reflectance in a fiber optic network FURUKAWA ELECTRIC NORTH AMERICA, INC. 2004-12-30 US claimed
US-8420764-B2 Compound having silsesquioxane skeleton and its polymer JNC CORPORATION (JP) 2013-04-16 US disclosed
US-8236917-B2 Compound having silsesquioxane skeleton and its polymer JNC CORPORATION (JP) 2012-08-07 US disclosed
US-20120178894-A1 COMPOUND HAVING SILSESQUIOXANE SKELETON AND ITS POLYMER INAGAKI JYUN-ICHI (JP) 2012-07-12 US disclosed
US-20100240855-A1 Compound having silsesquioxane skeleton and its polymer JNC CORPORATION (JP) 2010-09-23 US disclosed
US-7705105-B2 A cyclic polymer of silsesquioxane skeleton with side chains formed byhydrosilation of an unsaturated end group containing an active polymerfunctional group; polyimidesiloxane copolymers; polyestersiloxane copolymers; high molecular weight; thin films; strength; heat resistance;waterproofing; CHISSO PETROCHEMICAL CORPORATION (JP) 2010-04-27 US disclosed
US-20070190344-A1 Verification of translation JNC CORPORATION (JP) 2007-08-16 US disclosed
US-7031589-B2 Material for attenuating light signals with low reflectance in a fiber optic network FURUKAWA ELECTRIC NORTH AMERICA (US) 2006-04-18 US disclosed
US-20050009982-A1 Compound having silsesquioxane skeleton and its polymer CHISSO CORPORATION (JP) 2005-01-13 US disclosed
US-20040264908-A1 Material for attenuating light signals with low reflectance in a fiber optic network FURUKAWA ELECTRIC NORTH AMERICA, INC. 2004-12-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050009982-A1 Compound having silsesquioxane skeleton and its polymer C1S, H1-4, H1-0 MGLL 4700/4885GSK3A 2699/4885GSK3B 2311/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.