Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 6/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | LDHB | P07195 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3482900 | 0.89 | KMT2A (0.52) | CCR3TP53ADRB1HTR2AHTR2B | |
| SCHEMBL3482937 | 0.87 | KMT2A (0.50) | CCR3TP53ADRB1HTR2AHTR2B | |
| SCHEMBL3482303 | 0.85 | HSD17B10 (0.51) | CCR3ADRB1HTR2AHTR2BSIGMAR1 | |
| SCHEMBL3482768 | 0.83 | GFER (0.48) | CCR3ADRB1HTR2AHTR2BSIGMAR1 | |
| SCHEMBL3482588 | 0.82 | ADRB1 (0.49) | CCR3TP53ADRB1HTR2AHTR2B | |
| SCHEMBL3483021 | 0.81 | MC4R (0.46) | CCR3TP53MAPTALDH1A1KMT2A | |
| SCHEMBL3483019 | 0.80 | MAPT (0.53) | THRBADRB1HTR2AHTR2BSIGMAR1 | |
| SCHEMBL3482657 | 0.79 | ADRB1 (0.48) | CCR3TP53ADRB1HTR2AHTR2B | |
| SCHEMBL3482581 | 0.77 | ME2 (0.46) | CCR3TP53MAPTKDM4EALDH1A1 | |
| SCHEMBL2114345 | 0.77 | ADRB1 (0.76) | HTR1AADRB1HTR2AHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150550-A1 | NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK Holdings Co., Ltd. (KR) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008140197-A1 | NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK HOLDINGS CO., LTD. (KR) | 2008-11-20 | — | — | WO | disclosed |