⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3483628 | 0.87 | — | — | |
| SCHEMBL1949104 | 0.81 | — | — | |
| SCHEMBL30179538 | 0.74 | HDAC1 (0.39) | — | |
| SCHEMBL29250477 | 0.73 | LMNA (0.31) | — | |
| SCHEMBL4370106 | 0.73 | HSD17B10 (0.32) | — | |
| SCHEMBL3476705 | 0.71 | HSD17B10 (0.32) | — | |
| SCHEMBL8741061 | 0.71 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL1421057 | 0.70 | — | — | |
| SCHEMBL2169209 | 0.70 | LMNA (0.31) | — | |
| SCHEMBL29427561 | 0.70 | LMNA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3040347-A2 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-HB-EGF ANTIBODY AS ACTIVE INGREDIENT | Chugai Seiyaku Kabushiki Kaisha (JP) | 2016-07-06 | — | — | EP | disclosed |
| EP-2130552-B1 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-GRP78 ANTIBODY AS ACTIVE INGREDIENT | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2016-06-15 | — | — | EP | disclosed |
| US-20150246965-A1 | Pharmaceutical Composition Comprising Anti-HB-EGF Antibody as Active Ingredient | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2015-09-03 | — | — | US | disclosed |
| EP-2468771-A9 | PHARMACEUTICAL COMPOSITION CONTAINING ANTI-HB-EGF ANTIBODY AS ACTIVE INGREDIENT | Chugai Seiyaku Kabushiki Kaisha (JP) | 2014-01-08 | — | — | EP | disclosed |
| US-20120282173-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-HB-EGF ANTIBODY AS ACTIVE INGREDIENT | FORERUNNER PHARMA RESEARCH CO., LTD. (JP) | 2012-11-08 | — | — | US | disclosed |
| EP-2468771-A1 | PHARMACEUTICAL COMPOSITION CONTAINING ANTI-HB-EGF ANTIBODY AS ACTIVE INGREDIENT | Forerunner Pharma Research Co., Ltd. (JP) | 2012-06-27 | — | — | EP | disclosed |
| US-8192740-B2 | Pharmaceutical composition comprising anti-GRP78 antibody as active ingredient | FORERUNNER PHARMA RESEARCH CO., LTD. (JP) | 2012-06-05 | — | — | US | disclosed |
| US-20100061933-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-HB-EGF ANTIBODY AS ACTIVE INGREDIENT | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-03-11 | — | — | US | disclosed |
| US-20100041074-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-GRP78 ANTIBODY AS ACTIVE INGREDIENT | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-02-18 | — | — | US | disclosed |
| EP-2130552-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-GRP78 ANTIBODY AS ACTIVE INGREDIENT | Forerunner Pharma Research Co., Ltd. (JP) | 2009-12-09 | — | — | EP | disclosed |
| EP-2078731-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-HB-EGF ANTIBODY AS ACTIVE INGREDIENT | Forerunner Pharma Research Co., Ltd. (JP) | 2009-07-15 | — | — | EP | disclosed |