⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3483237 | 0.87 | — | — | |
| SCHEMBL2158048 | 0.70 | LMNA (0.39) | — | |
| SCHEMBL561821 | 0.70 | RAB9A (0.37) | — | |
| SCHEMBL6034749 | 0.69 | HDAC1 (0.44) | — | |
| SCHEMBL29250765 | 0.69 | LMNA (0.36) | — | |
| SCHEMBL28514925 | 0.68 | LMNA (0.45) | — | |
| SCHEMBL465750 | 0.68 | LMNA (0.37) | — | |
| SCHEMBL3696095 | 0.68 | LMNA (0.41) | — | |
| SCHEMBL5577177 | 0.67 | CNR2 (0.35) | — | |
| SCHEMBL4184231 | 0.67 | MEN1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130552-B1 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-GRP78 ANTIBODY AS ACTIVE INGREDIENT | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2016-06-15 | — | — | EP | disclosed |
| US-8192740-B2 | Pharmaceutical composition comprising anti-GRP78 antibody as active ingredient | FORERUNNER PHARMA RESEARCH CO., LTD. (JP) | 2012-06-05 | — | — | US | disclosed |
| US-20100041074-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-GRP78 ANTIBODY AS ACTIVE INGREDIENT | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-02-18 | — | — | US | disclosed |
| EP-2130552-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ANTI-GRP78 ANTIBODY AS ACTIVE INGREDIENT | Forerunner Pharma Research Co., Ltd. (JP) | 2009-12-09 | — | — | EP | disclosed |