Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 6/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.47 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234201 | 0.84 | GRM2 (0.58) | FADS1GRM2PRSS12HTR2A | |
| SCHEMBL13413433 | 0.84 | FADS1 (0.53) | FADS1GRM2 | |
| SCHEMBL13547539 | 0.84 | FADS1 (0.53) | FADS1GRM2 | |
| SCHEMBL14734294 | 0.84 | FADS1 (0.53) | FADS1GRM2 | |
| SCHEMBL13413437 | 0.82 | HTR6 (0.52) | FADS1GRM2MDM2 | |
| SCHEMBL15689116 | 0.82 | FADS1 (0.48) | FADS1GRM2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13413561 | 0.81 | GRM2 (0.45) | FADS1GRM2 | |
| SCHEMBL13413436 | 0.81 | CETP (0.44) | FADS1GRM2BRD4BRDT | |
| SCHEMBL2297998 | 0.79 | MDM2 (0.44) | FADS1GRM2SRD5A1DRD2MDM2 | |
| SCHEMBL2294621 | 0.79 | MDM2 (0.44) | FADS1GRM2SRD5A1DRD2MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257536-A2 | CYCLIC DIARYL ETHER AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009102893-A2 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |