Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3483668 | 0.88 | MGLL (0.49) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL18002248 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL15677565 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL13741500 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL2371661 | 0.78 | MEN1 (0.58) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL1644780 | 0.78 | MEN1 (0.52) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL2192192 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAHTTL3MBTL1SYK | |
| SCHEMBL291124 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL8149899 | 0.75 | LMNA (0.59) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL21985416 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257536-A2 | CYCLIC DIARYL ETHER AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009102893-A2 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |