Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2075254 | 0.82 | LMNA (0.62) | PTGDR2LMNAGAAKMT2AERN1 | |
| SCHEMBL2753212 | 0.80 | MAPK1 (0.55) | LMNAKMT2AALDH1A1SLC6A4HTR6 | |
| SCHEMBL3484746 | 0.80 | L3MBTL1 (0.39) | LMNAGAAKMT2ANPSR1ALDH1A1 | |
| SCHEMBL2753829 | 0.77 | MAPK1 (0.37) | LMNAKMT2AALDH1A1SLC6A4HTR6 | |
| SCHEMBL12438312 | 0.75 | MAOB (0.45) | PTGDR2LMNAGAAKMT2AERN1 | |
| SCHEMBL21371124 | 0.75 | NPSR1 (0.51) | PTGDR2LMNAGAAKMT2AERN1 | |
| SCHEMBL276480 | 0.75 | EPAS1 (0.49) | PTGDR2LMNAGAAKMT2AERN1 | |
| SCHEMBL3484951 | 0.74 | PTGDR2 (0.44) | PTGDR2LMNAKMT2AALDH1A1SLC6A4 | |
| SCHEMBL19865453 | 0.73 | EPAS1 (0.49) | PTGDR2LMNAGAAKMT2AERN1 | |
| SCHEMBL274863 | 0.73 | PTGDR2 (0.48) | PTGDR2LMNAGAAKMT2AERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257536-A2 | CYCLIC DIARYL ETHER AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009102893-A2 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |