Fluorescein

Fluorescein

SCHEMBL3485550

O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccccc21.OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 9/20 0.69
MAPT P10636 4/20 0.69
MEN1 O00255 3/20 0.69
KMT2A Q03164 3/20 0.69
HTT P42858 2/20 0.69
TDP1 Q9NUW8 2/20 0.69
HPGD P15428 2/20 0.69
CYP2C19 P33261 1/20 0.69
RECQL P46063 1/20 0.69
BLM P54132 1/20 0.69
SMAD3 P84022 1/20 0.69
PRMT1 Q99873 1/20 0.69
ACE2 Q9BYF1 1/20 0.69
LMNA P02545 3/20 0.50
GPR55 Q9Y2T6 2/20 0.50
ALOX12 P18054 2/20 0.50
POLB P06746 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
CYP3A4 P08684 2/20 0.47
ALDH1A1 P00352 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluorescein SCHEMBL1034246 1.00 FTO (0.69) FTOMAPTMEN1KMT2AHTT
SCHEMBL29661300 0.87 MAPT (0.59) FTOMAPTMEN1KMT2AHTT
SCHEMBL20777527 0.87 MAPT (0.59) FTOMAPTMEN1KMT2AHTT
SCHEMBL10710403 0.87 MAPT (0.59) FTOMAPTMEN1KMT2AHTT
SCHEMBL3695146 0.87 MAPT (0.59) FTOMAPTMEN1KMT2AHTT
SCHEMBL1029869 0.87 MAPT (0.59) FTOMAPTMEN1KMT2AHTT
SCHEMBL597089 0.87 MAPT (0.59) FTOMAPTMEN1KMT2AHTT
SCHEMBL869219 0.87 MAPT (0.59) FTOMAPTMEN1KMT2AHTT
Fluorescein SCHEMBL1973302 0.84 FTO (0.97) FTOMAPTMEN1KMT2AHTT
Fluorescein SCHEMBL29025259 0.83 FTO (0.89) FTOMAPTMEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100015148-A1 METHODS AND COMPOSITIONS FOR THE UTILIZATION AND TARGETING OF OSTEOMIMICRY DA ZEN GROUP, LLC (US) 2010-01-21 US disclosed
US-20090028832-A1 Compositions and methods for targeted tumor therapy CHUNG LELAND F 2009-01-29 US disclosed
US-20070078085-A1 Methods and compositions for the utilization and targeting of osteomimicry CHUNG, LELAND W.K., DR. 2007-04-05 US disclosed
US-7132274-B2 Method for identifying modulators of CLK-1 and UbiF activity MCGILL UNIVERSITY (CA) 2006-11-07 US disclosed
WO-2006044486-A2 METHODS AND COMPOSITIONS FOR THE UTILIZATION AND TARGETING OF OSTEOMIMICRY DENZAI THERAPEUTICS CORPORATION (US) 2006-04-27 WO disclosed
EP-1620723-A1 METHOD FOR IDENTIFYING MODULATORS OF CLK-1 AND UBIF ACTIVITY McGILL UNIVERSITY (CA) 2006-02-01 EP disclosed
US-20040265989-A1 Method for identifying modulators of CLK-1 and UbiF activity MCGILL UNIVERSITY 2004-12-30 US disclosed
US-6825035-B1 FOR DRUG SCREENING; GENE KNOCKOUT; GENETIC ENGINEERING SETAGON, INC. 2004-11-30 US disclosed
WO-2004099770-A1 METHOD FOR IDENTIFYING MODULATORS OF CLK-1 AND UBIF ACTIVITY MCGILL UNIVERSITY (CA) 2004-11-18 WO disclosed
EP-1226151-A4 GENE EXPRESSION DIRECTED BY A SUPER-PSA PROMOTER UNIV VIRGINIA (US) 2004-07-14 EP disclosed
WO-2000032619-A1 METHODS AND COMPOSITIONS FOR IDENTIFICATION OF INHIBITORS OF RIBOSOME ASSEMBLY RIBOGENE, INC. (US) 2000-06-08 WO disclosed
WO-2000024254-A1 COMPOSITIONS AND METHODS FOR MODULATING EXPRESSION WITHIN SMOOTH MUSCLE CELLS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2000-05-04 WO disclosed
WO-2000005417-A1 METHODS AND COMPOSITIONS FOR THE DETERMINATION OF PROTEIN FUNCTION AND IDENTIFICATION OF MODULATORS THEREOF SMALL MOLECULE THERAPEUTICS, INC. (US) 2000-02-03 WO disclosed
EP-0975969-A1 METHODS FOR SCREENING COMPOUNDS USING ENCAPSULATED CELLS Chromaxome Corp. (US) 2000-02-02 EP disclosed
WO-2000000604-A1 METHODS AND COMPOSITIONS FOR MODULATING SPERMATOGENESIS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2000-01-06 WO disclosed
US-5998159-A MEASURING ACCUMULATION OF BACTERIA RIBOGENE, INC. (US) 1999-12-07 US disclosed
WO-1999023116-A9 ASSAY EMPLOYING CadC FUSION PROTEINS SMALL MOLECULE THERAPEUTICS IN (US) 1999-09-02 WO disclosed
WO-1999023116-A1 ASSAY EMPLOYING CadC FUSION PROTEINS SMALL MOLECULE THERAPEUTICS, INC. (US) 1999-05-14 WO disclosed
WO-1998041869-A1 METHODS FOR SCREENING COMPOUNDS USING ENCAPSULATED CELLS CHROMAXOME CORPORATION (US) 1998-09-24 WO disclosed
WO-1998035054-A1 METHODS FOR SCREENING FOR ANTIBIOTICS RIBOGENE, INC. (US) 1998-08-13 WO disclosed