Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 13/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485464 | 0.89 | MAP3K5 (0.57) | MAP3K5GAAKDM4ELMNAMAPT | |
| SCHEMBL3485303 | 0.87 | MAP3K5 (0.67) | MAP3K5GAAKDM4ELMNAMAPT | |
| Hydrochloric Acid SCHEMBL3486394 | 0.86 | MAP3K5 (0.66) | MAP3K5GAAKDM4ELMNAMAPT | |
| SCHEMBL3486573 | 0.80 | MAP3K5 (0.50) | MAP3K5GAAKDM4ELMNAMAPT | |
| SCHEMBL3486023 | 0.80 | MAP3K5 (0.76) | MAP3K5CLK2HRH1PDGFRBKIT | |
| SCHEMBL3485656 | 0.79 | MAP3K5 (0.47) | MAP3K5GAAKDM4ELMNAMAPT | |
| SCHEMBL3486308 | 0.77 | MAP3K5 (0.49) | MAP3K5CLK2HRH1PDGFRBKIT | |
| SCHEMBL3485399 | 0.76 | KDM4E (0.45) | MAP3K5GAAKDM4ELMNAMAPT | |
| SCHEMBL3485623 | 0.76 | MAP3K5 (0.77) | MAP3K5CLK2HRH1PDGFRBKIT | |
| SCHEMBL3485831 | 0.76 | MAP3K5 (0.60) | MAP3K5CLK2HRH1PDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-02-04 | — | — | US | disclosed |
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-02-04 | — | — | US | disclosed |
| US-20100028952-A1 | FERMENTATION AND PURIFICATION OF ACTINOMADURA CHROMOPROTEIN AND RELATED SPECIES | WYETH (US) | 2010-02-04 | — | — | US | disclosed |
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-02-04 | — | — | US | disclosed |
| EP-2058309-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-05-13 | — | — | EP | disclosed |
| EP-2058309-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-05-13 | — | — | EP | disclosed |
| EP-2029175-A2 | FERMENTATION AND PURIFICATION OF ACTINOMADURA CHROMOPROTEIN AND RELATED SPECIES | Wyeth (US) | 2009-03-04 | — | — | EP | disclosed |
| US-20080274959-A1 | Actinomadura Chromoprotein, Apoprotein and Gene Cluster | WYETH (US) | 2008-11-06 | — | — | US | disclosed |
| WO-2007149560-A2 | FERMENTATION AND PURIFICATION OF ACTINOMADURA CHROMOPROTEIN AND RELATED SPECIES | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |
| EP-1836219-A2 | ACTINOMADURA CHROMOPROTEIN, APOPROTEIN, AND GENE CLUSTER | Wyeth (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006066153-A2 | ACTINOMADURA CHROMOPROTEIN, APOPROTEIN, AND GENE CLUSTER | WYETH (US) | 2006-06-22 | — | — | WO | disclosed |
| EP-1381672-A4 | BIOSYNTHESIS OF POLYKETIDE SYNTHASE SUBSTRATES | TRUSTEES OF BOARD OF (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1381672-A1 | BIOSYNTHESIS OF POLYKETIDE SYNTHASE SUBSTRATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2004-01-21 | — | — | EP | disclosed |
| US-20020192767-A1 | Biosynthesis of polyketide synthase substrates | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-12-19 | — | — | US | disclosed |
| WO-2002068613-A1 | BIOSYNTHESIS OF POLYKETIDE SYNTHASE SUBSTRATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2002-09-06 | — | — | WO | disclosed |
| US-20020045220-A1 | Biosynthesis of polyketide synthase substrates | LELAND STANFORD JUNIOR UNIVERSITY, THE | 2002-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080274959-A1 | Actinomadura Chromoprotein, Apoprotein and Gene Cluster | ACTR2, APOB, CACYBP | MAP3K5 3025/4885GAA 2227/4885KDM4E 4682/4885 |
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | IRAK1, IL1R1, IRAK2 | MAP3K5 42/4885GAA 4092/4885KDM4E 898/4885 |
| US-20020045220-A1 | Biosynthesis of polyketide synthase substrates | COASY, DCXR, KYAT3 | MAP3K5 2956/4885GAA 295/4885KDM4E 1485/4885 |
| US-20100028952-A1 | FERMENTATION AND PURIFICATION OF ACTINOMADURA CHROMOPROTEIN AND RELATED SPECIES | DCXR, ACTR2, AMY2A | MAP3K5 2799/4885GAA 82/4885KDM4E 3138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.