Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.41 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487130 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL3487485 | 0.88 | HSPB1 (0.43) | SMN1; SMN2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL3488707 | 0.87 | HSPB1 (0.43) | SMN1; SMN2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL3487360 | 0.87 | HSPB1 (0.46) | LPAR1LPAR5KMT2AMEN1F10 | |
| SCHEMBL3487405 | 0.85 | TBXA2R (0.40) | SMN1; SMN2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL3487594 | 0.85 | ALDH1A1 (0.40) | SMN1; SMN2KMT2AMEN1POLBHPGD | |
| SCHEMBL3488698 | 0.84 | ALDH1A1 (0.43) | SMN1; SMN2KMT2AMEN1POLBHPGD | |
| SCHEMBL3486660 | 0.83 | ALDH1A1 (0.45) | SMN1; SMN2CYP2C9CYP2C19NPSR1LPAR1 | |
| SCHEMBL3486663 | 0.83 | ALDH1A1 (0.45) | SMN1; SMN2CYP2C9CYP2C19NPSR1LPAR1 | |
| SCHEMBL3486956 | 0.82 | HSD17B1 (0.48) | SMN1; SMN2KMT2AMEN1FFAR1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2138484-B1 | FUSED BICYCLIC HETEROARYL DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2015-08-26 | — | — | EP | disclosed |
| US-20130035337-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-02-07 | — | — | US | disclosed |
| US-20100048564-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2138484-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2009-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035337-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | PPARG, GPR119, PPARA | SMN1; SMN2 4397/4885CYP1A2 653/4885CYP2C9 848/4885 |
| US-20100048564-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | PPARG, GPR119, PPARA | SMN1; SMN2 4397/4885CYP1A2 653/4885CYP2C9 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.