⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29550485 | 1.00 | — | — | |
| SCHEMBL28405058 | 0.84 | NPC1 (0.35) | — | |
| SCHEMBL4489100 | 0.76 | NPC1 (0.42) | — | |
| SCHEMBL4488828 | 0.76 | ALDH1A1 (0.43) | — | |
| SCHEMBL2008333 | 0.75 | ALOX5 (0.54) | — | |
| SCHEMBL4501793 | 0.73 | MAPT (0.46) | — | |
| SCHEMBL7454690 | 0.69 | MAOA (0.52) | — | |
| SCHEMBL10047427 | 0.69 | MAOB (0.38) | — | |
| SCHEMBL5304361 | 0.69 | — | — | |
| SCHEMBL14084321 | 0.67 | GAA (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060052372-A1 | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders | ALCON RESEARCH, LTD. | 2006-03-09 | — | — | US | claimed |
| US-20050187214-A1 | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders | ALCON RESEARCH, LTD. | 2005-08-25 | — | — | US | claimed |
| EP-1079763-A2 | SEROTONERGIC 5HT 7? RECEPTOR COMPOUNDS FOR TREATING OCULAR AND CNS DISORDERS | ALCON LABORATORIES, INC. (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999059499-A2 | SEROTONERGIC 5HT7 RECEPTOR COMPOUNDS FOR TREATING OCULAR AND CNS DISORDERS | ALCON LABORATORIES, INC. (US) | 1999-11-25 | — | — | WO | claimed |
| WO-2025049250-A1 | 6,6-CORE SILACYCLE BASED INHIBITORS OF DNA-DEPENDENT PROTEIN KINASE AND COMPOSITIONS AND APPLICATION IN GENE EDITING | JUNO THERAPEUTICS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |
| US-20240083908-A1 | TETRAHYDROTHIENOPYRIMIDINESULFONAMIDE COMPOUNDS | ALIVEXIS, INC. (JP) | 2024-03-14 | — | — | US | disclosed |
| EP-4269415-A1 | TETRAHYDRO THIENOPYRIDINE SULFONAMIDE COMPOUND | Modulus Discovery, Inc. (JP) | 2023-11-01 | — | — | EP | disclosed |
| CN-116583286-A | Tetrahydrothienopyrimidine sulfonamide compounds | 某久拉斯株式会社 | 2023-08-11 | — | — | CN | disclosed |
| WO-2022138812-A1 | TETRAHYDRO THIENOPYRIDINE SULFONAMIDE COMPOUND | モジュラス株式会社 | 2022-06-30 | — | — | WO | disclosed |
| US-20210395231-A1 | RECEPTOR INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USE THEREOF | BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) | 2021-12-23 | — | — | US | disclosed |
| US-20210054007-A1 | RECEPTOR INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) | 2021-02-25 | — | — | US | disclosed |
| EP-3760620-A1 | RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USAGE THEREOF | Beijing Tide Pharmaceutical Co., Ltd. (CN) | 2021-01-06 | — | — | EP | disclosed |
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |
| US-7060704-B2 | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders | ALCON MANUFACTURING, LTD. (US) | 2006-06-13 | — | — | US | disclosed |
| US-20060052372-A1 | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders | ALCON RESEARCH, LTD. | 2006-03-09 | — | — | US | disclosed |
| US-6960579-B1 | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders | ALCON MANUFACTURING, LTD. (US) | 2005-11-01 | — | — | US | disclosed |
| US-20050187214-A1 | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders | ALCON RESEARCH, LTD. | 2005-08-25 | — | — | US | disclosed |
| EP-1079763-A2 | SEROTONERGIC 5HT 7? RECEPTOR COMPOUNDS FOR TREATING OCULAR AND CNS DISORDERS | ALCON LABORATORIES, INC. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059499-A2 | SEROTONERGIC 5HT7 RECEPTOR COMPOUNDS FOR TREATING OCULAR AND CNS DISORDERS | ALCON LABORATORIES, INC. (US) | 1999-11-25 | — | — | WO | disclosed |