Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3488270 | 0.82 | PGR (0.49) | NR3C2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3489982 | 0.80 | SLC2A1 (0.54) | NR3C2TP53 | |
| SCHEMBL3489954 | 0.79 | MAPT (0.39) | NR3C2GRIN1GRIN2BALDH1A1 | |
| SCHEMBL3488787 | 0.78 | NR3C2 (0.50) | NR3C2P2RX7RIPK3KDM4E | |
| SCHEMBL3489611 | 0.77 | MAPT (0.52) | NR3C2NPC1KDM4EALDH1A1 | |
| SCHEMBL3489593 | 0.77 | PGR (0.53) | NR3C2GRIN1GRIN2BP2RX7LMNA | |
| SCHEMBL3489690 | 0.77 | GRIN2B (0.55) | NR3C2GRIN1GRIN2BNPC1TP53 | |
| SCHEMBL3488088 | 0.76 | SLC2A1 (0.50) | NR3C2LMNARAB9ANPC1TP53 | |
| SCHEMBL3488754 | 0.75 | L3MBTL1 (0.47) | NR3C2LMNARAB9ANPC1TP53 | |
| SCHEMBL3488206 | 0.74 | GRIN1 (0.52) | NR3C2GRIN1GRIN2BP2RX7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | NR3C2, MC2R, NR3C1 | NR3C2 1/4885GRIN1 778/4885GRIN2B 965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.