Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | ARAF | P10398 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3488408 | 0.89 | SMN1; SMN2 (0.35) | SMN1; SMN2HSD17B1HSD17B2RAF1ARAF | |
| SCHEMBL3488383 | 0.88 | PARP10 (0.45) | SMN1; SMN2HSD17B1HSD17B2RAF1ARAF | |
| SCHEMBL3487615 | 0.87 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2HSD17B1HSD17B2KDM4E | |
| SCHEMBL3488933 | 0.86 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HSD17B1HSD17B2BRAF | |
| SCHEMBL3488177 | 0.85 | HSD17B1 (0.44) | ALDH1A1SMN1; SMN2HSD17B1HSD17B2BRAF | |
| SCHEMBL3455019 | 0.85 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HSD17B1HSD17B2KDM4E | |
| SCHEMBL3487215 | 0.84 | HSD17B1 (0.52) | ALDH1A1SMN1; SMN2HSD17B1HSD17B2POLB | |
| SCHEMBL3488037 | 0.82 | ALDH1A1 (0.39) | ALDH1A1RAF1ARAFBRAFHDAC1 | |
| SCHEMBL3488405 | 0.81 | TDP1 (0.42) | ALDH1A1SMN1; SMN2HSD17B1HSD17B2POLB | |
| SCHEMBL3487922 | 0.81 | POLB (0.41) | ALDH1A1SMN1; SMN2RAF1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2138484-B1 | FUSED BICYCLIC HETEROARYL DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2015-08-26 | — | — | EP | disclosed |
| US-20100048564-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2138484-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2009-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048564-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | PPARG, GPR119, PPARA | ALDH1A1 698/4885SMN1; SMN2 4397/4885HSD17B1 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.