Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitrobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.84 |
| ▸ | LMNA | P02545 | 2/20 | 0.84 |
| ▸ | CES1 | P23141 | 3/20 | 0.65 |
| ▸ | CES2 | O00748 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrobenzene SCHEMBL27075815 | 1.00 | ALDH1A1 (0.84) | ALDH1A1LMNACES1CES2TDP1 | |
| Nitrobenzene SCHEMBL2029354 | 1.00 | ALDH1A1 (0.84) | ALDH1A1LMNACES1CES2TDP1 | |
| Nitrobenzene SCHEMBL6858789 | 1.00 | ALDH1A1 (0.84) | ALDH1A1LMNACES1CES2TDP1 | |
| Nitrobenzene SCHEMBL9178806 | 0.97 | ALDH1A1 (0.80) | ALDH1A1LMNACES1CES2TDP1 | |
| Nitrobenzene SCHEMBL11825863 | 0.92 | ALDH1A1 (0.80) | ALDH1A1LMNACES1CES2TDP1 | |
| Nitrobenzene SCHEMBL27304275 | 0.92 | ALDH1A1 (0.89) | ALDH1A1LMNACES1CES2TDP1 | |
| Nitrobenzene SCHEMBL15525745 | 0.92 | ALDH1A1 (1.00) | ALDH1A1LMNACES1CES2TDP1 | |
| Nitrobenzene SCHEMBL2358164 | 0.92 | ALDH1A1 (1.00) | ALDH1A1LMNACES1CES2TDP1 | |
| Nitrobenzene SCHEMBL20411 | 0.92 | — | — | |
| Nitrobenzene SCHEMBL9669095 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240261221-A1 | POLYOL-MODIFIED LIPID COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | JENKEM TECHNOLOGY CO., LTD. (TIANJIN) (CN) | 2024-08-08 | — | — | US | claimed |
| EP-4365168-A1 | POLYOL-MODIFIED LIPID COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | Jenkem Technology Co., Ltd. (Tianjin) (CN) | 2024-05-08 | — | — | EP | claimed |
| CN-115403761-A | Polyglycol modified lipid compound and preparation method and application thereof | 天津键凯科技有限公司 | 2022-11-29 | — | — | CN | claimed |
| WO-2022095974-A1 | METHOD FOR PREPARING POLYETHYLENE GLYCOL-MODIFIED URATE OXIDASE | 杭州远大生物制药有限公司 | 2022-05-12 | — | — | WO | claimed |
| WO-2020228618-A1 | POLYETHYLENE GLYCOL-MODIFIED URATE OXIDASE | 重庆派金生物科技有限公司 | 2020-11-19 | — | — | WO | claimed |
| CN-106977577-A | The synthesis of two class abiraterone derivatives | 湖南师范大学 | 2017-07-25 | — | — | CN | claimed |
| CN-1201055-A | Beta-quinacridone pigment | CIBA SC AOLDING AG (CH) | 1998-12-09 | — | — | CN | claimed |
| US-12618109-B2 | Orthogonal deblocking of nucleotides | ILLUMINA, INC. (US) | 2026-05-05 | — | — | US | disclosed |
| EP-4727690-A1 | FLOW CELLS AND METHODS FOR PREPARING SURFACES THEREOF | Illumina, Inc. (US) | 2026-04-22 | — | — | EP | disclosed |
| EP-4426859-B1 | PRIMER SETS AND METHODS AND KITS INCORPORATING THE PRIMER SETS | ILLUMINA INC (US) | 2026-04-15 | — | — | EP | disclosed |
| EP-4721762-A2 | MODIFIED POLYAMINE POLYMERS FOR DELIVERY OF BIOMOLECULES INTO CELLS | Promega Corporation (US) | 2026-04-08 | — | — | EP | disclosed |
| EP-3725798-B1 | BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF | SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN) | 2026-03-04 | — | — | EP | disclosed |
| EP-4667495-A2 | BIOACTIVE MOLECULE CONJUGATE, PREPARATION METHOD AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2025-12-24 | — | — | EP | disclosed |
| WO-1991006678-A1 | DNA SEQUENCING | SRI INTERNATIONAL (US) | 1991-05-16 | — | — | WO | disclosed |
| EP-0051559-B1 | BASIC AND/OR CATIONIC AZO COMPOUNDS FREE FROM SULFONIC-ACID GROUPS | SANDOZ AG (CH) | 1984-11-07 | — | — | EP | disclosed |
| EP-0034257-B1 | PROCESS FOR THE PREPARATION OF 1,4-DIAMINO-2,3-DICYANO-ANTHRAQUINONE | BAYER AG (DE) | 1983-01-26 | — | — | EP | disclosed |
| EP-0023645-B1 | PROCESS FOR THE PREPARATION OF 1,4-DIAMINO-2,3-DICYANOANTHRAQUINONES | BAYER AG (DE) | 1982-07-28 | — | — | EP | disclosed |
| EP-0051559-A1 | Basic and/or cationic azo compounds free from sulfonic-acid groups | SANDOZ AG (CH) | 1982-05-12 | — | — | EP | disclosed |
| EP-0034257-A2 | Process for the preparation of 1,4-diamino-2,3-dicyano-anthraquinone | BAYER AG (DE) | 1981-08-26 | — | — | EP | disclosed |
| EP-0023645-A1 | Process for the preparation of 1,4-diamino-2,3-dicyanoanthraquinones | BAYER AG (DE) | 1981-02-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240261221-A1 | POLYOL-MODIFIED LIPID COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | PLIN1, NOTUM, THEM6 | ALDH1A1 3652/4885LMNA 947/4885CES1 1029/4885 |
| US-12618109-B2 | Orthogonal deblocking of nucleotides | RNGTT, POLM, NSUN2 | ALDH1A1 3202/4885LMNA 421/4885CES1 4347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.