Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492216 | 0.78 | GSK3B (0.48) | RAB9ASMN1; SMN2KDM4EGAANPC1 | |
| SCHEMBL3493539 | 0.78 | ALDH1A1 (0.41) | RAB9ASMN1; SMN2KDM4EMTNR1AALDH1A1 | |
| SCHEMBL3491311 | 0.70 | GSK3B (0.39) | NPC1POLBGSK3B | |
| SCHEMBL3493195 | 0.63 | GSK3B (0.51) | RAB9ASMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL3493171 | 0.61 | GSK3B (0.41) | RAB9ASMN1; SMN2KDM4EGAANPC1 | |
| SCHEMBL7657622 | 0.59 | LMNA (0.45) | RAB9ASMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL3491360 | 0.59 | MTNR1A (0.38) | SMN1; SMN2NPC1POLBMTNR1AALDH1A1 | |
| SCHEMBL3491363 | 0.59 | MTNR1A (0.38) | SMN1; SMN2NPC1POLBMTNR1AALDH1A1 | |
| SCHEMBL3492505 | 0.58 | GSK3B (0.42) | RAB9ASMN1; SMN2KDM4ENPC1GSK3B | |
| SCHEMBL3491134 | 0.58 | GSK3B (0.58) | RAB9ANPC1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492378-B2 | GSK-3β inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-23 | — | — | US | disclosed |
| US-20100069381-A1 | GSK-3BETAINHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069381-A1 | GSK-3BETAINHIBITOR | GSK3B, GSK3A, GSKIP | RAB9A 3231/4885SMN1; SMN2 1036/4885KDM4E 1112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.