Guanosine

Guanosine

SCHEMBL3492467

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.O=c1[nH]c(=O)c2[nH]cnc2[nH]1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.59
HINT1 P49773 5/20 0.55
NT5E P21589 1/20 0.55
GSK3A P49840 2/20 0.54
RPS6KA3 P51812 2/20 0.54
MAPK14 Q16539 2/20 0.54
TGM2 P21980 1/20 0.53
PNP P00491 2/20 0.52
PAX8 Q06710 1/20 0.52
ADORA2A P29274 2/20 0.51
ADORA2B P29275 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL936682 0.96 HPGD (0.55) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL8995759 0.89 HPGD (0.62) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL3055871 0.88 HPGD (0.63) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL531207 0.87 HPGD (0.76) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL24049608 0.87 HPGD (0.76) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL24049417 0.87 HPGD (0.76) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL24049467 0.87 HPGD (0.76) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL20750695 0.87 HPGD (0.76) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL413586 0.87 HPGD (0.76) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL24049416 0.87 HPGD (0.76) HPGDHINT1NT5EGSK3ARPS6KA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100075414-A1 GROWTH OF FOREIGN CELLS AFTER CONDITIONAL AND SELECTIVE DESTRUCTION OF FETAL HOST CELLS XIMEREX, INC. (US) 2010-03-25 US claimed
US-7626075-B2 Growth of foreign cells in fetal animals facilitated by conditional and selective destruction of native host cells XIMEREX, INC. (US) 2009-12-01 US claimed
US-20070134212-A1 Growth of foreign cells in fetal animals facilitated by conditional and selective destruction of native host cells XIMEREX, INC. (US) 2007-06-14 US claimed
EP-1545215-A2 GROWTH OF FOREIGN CELLS IN FETAL ANIMALS FACILITATED BY CONDITIONAL AND SELECTIVE DESTRUCTION OF NATIVE HOST CELLS Ximerex, Inc. (US) 2005-06-29 EP claimed
WO-2004027029-A2 GROWTH OF FOREIGN CELLS IN FETAL ANIMALS FACILITATED BY CONDITIONAL AND SELECTIVE DESTRUCTION OF NATIVE HOST CELLS XIMEREX, INC. (US) 2004-04-01 WO claimed
US-20100075414-A1 GROWTH OF FOREIGN CELLS AFTER CONDITIONAL AND SELECTIVE DESTRUCTION OF FETAL HOST CELLS XIMEREX, INC. (US) 2010-03-25 US disclosed
US-7626075-B2 Growth of foreign cells in fetal animals facilitated by conditional and selective destruction of native host cells XIMEREX, INC. (US) 2009-12-01 US disclosed
EP-1855534-A4 FACILITATED CELLULAR RECONSTITUTION OF ORGANS AND TISSUES DIAMOND PAUL (US) 2008-12-17 EP disclosed
EP-1855534-A2 FACILITATED CELLULAR RECONSTITUTION OF ORGANS AND TISSUES Diamond, Paul (US) 2007-11-21 EP disclosed
US-20070240235-A1 METHODS FOR SUPPORTING AND PRODUCING HUMAN CELLS AND TISSUES IN NON-HUMAN MAMMAL HOSTS DIAMOND PAUL 2007-10-11 US disclosed
US-20070134212-A1 Growth of foreign cells in fetal animals facilitated by conditional and selective destruction of native host cells XIMEREX, INC. (US) 2007-06-14 US disclosed
WO-2006074012-A2 FACILITATED CELLULAR RECONSTITUTION OF ORGANS AND TISSUES DIAMOND PAUL (US) 2006-07-13 WO disclosed
EP-0282512-A1 MESSENGER RNA STABILIZATION IN ANIMAL CELLS DAMON BIOTECH, INC. (US) 1988-09-21 EP disclosed
EP-0272315-A1 RECOMBINANT HUMAN TISSUE PLASMINOGEN ACTIVATOR COMPOSITION DAMON BIOTECH, INC. (US) 1988-06-29 EP disclosed
WO-1988002029-A1 MESSENGER RNA STABILIZATION IN ANIMAL CELLS DAMON BIOTECH, INC. (US) 1988-03-24 WO disclosed
WO-1988000242-A1 RECOMBINANT HUMAN TISSUE PLASMINOGEN ACTIVATOR COMPOSITION DAMON BIOTECH, INC. (US) 1988-01-14 WO disclosed
EP-0237157-A2 Vector and method for achieving high level expression in cells Abbott Biotech, Inc. (US) 1987-09-16 EP disclosed
EP-0191606-A2 Vectors and methods for expression of human protein C activity ELI LILLY AND COMPANY (US) 1986-08-20 EP disclosed
EP-0172194-A1 CONTROL SYSTEMS FOR RECOMBINANT MANIPULATIONS. CETUS CORP (US) 1986-02-26 EP disclosed
WO-1985003522-A1 MONITORING AND CONTROL SYSTEMS FOR RECOMBINANT MANIPULATIONS CETUS CORPORATION (US) 1985-08-15 WO disclosed