Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.45 |
| ▸ | GAPDH | P04406 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687832 | 0.89 | KDM4E (0.71) | KDM4EPKMADORA3LMNANT5E | |
| SCHEMBL5489450 | 0.82 | ADORA3 (0.64) | KDM4EPKMADORA3POLBADORA2A | |
| SCHEMBL5489442 | 0.82 | ADORA3 (0.64) | KDM4EPKMADORA3POLBADORA2A | |
| SCHEMBL14580421 | 0.82 | ADORA3 (0.64) | KDM4EPKMADORA3POLBADORA2A | |
| SCHEMBL1507731 | 0.82 | ADORA3 (0.64) | KDM4EPKMADORA3POLBADORA2A | |
| SCHEMBL25424615 | 0.82 | ADORA3 (0.64) | KDM4EPKMADORA3POLBADORA2A | |
| SCHEMBL1494485 | 0.78 | KDM4E (0.69) | KDM4EPKMADORA3LMNANT5E | |
| SCHEMBL23710624 | 0.78 | KDM4E (0.69) | KDM4EPKMADORA3LMNANT5E | |
| SCHEMBL29471286 | 0.78 | KDM4E (0.69) | KDM4EPKMADORA3LMNANT5E | |
| SCHEMBL1494490 | 0.78 | KDM4E (0.69) | KDM4EPKMADORA3LMNANT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100136693-A1 | Mutants of Deoxycytidine Kinase Having Extended Enzymatic Activity | INSTITUT PASTEUR AND THE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2010-06-03 | — | — | US | disclosed |
| US-7547513-B2 | Mutants of deoxycytidine kinase having extended enzymatic activity | INSTITUT PASTEUR (FR) | 2009-06-16 | — | — | US | disclosed |
| US-20070037269-A1 | Artificial in vivo evolution of protein X by complementation of a relative protein Y,X and Y both belonging to the same class of enzyme commission nomenclature or belonging to related classes, result in acquisition of thymidine kinase activity by DCK | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-02-15 | — | — | US | disclosed |