Buciclovir

Buciclovir

SCHEMBL349779

Nc1nc2c(ncn2CC[C@@H](O)CO)c(=O)[nH]1

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TK1 P04183 2/20 0.67
BLM P54132 2/20 0.63
MEN1 O00255 1/20 0.63
ALDH1A1 P00352 1/20 0.63
LMNA P02545 1/20 0.63
CYP3A4 P08684 1/20 0.63
NFKB1 P19838 1/20 0.63
VCP P55072 1/20 0.63
KMT2A Q03164 1/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
HIF1A Q16665 1/20 0.63
HPRT1 P00492 9/20 0.63
PNP P00491 5/20 0.59
USP2 O75604 1/20 0.59
TSHR P16473 1/20 0.59
EDNRA P25101 1/20 0.59
HTR2A P28223 1/20 0.59
RECQL P46063 1/20 0.59
HBB P68871 1/20 0.59
HSD17B10 Q99714 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Buciclovir SCHEMBL10918840 1.00 TK1 (0.67) TK1BLMMEN1ALDH1A1LMNA
Buciclovir SCHEMBL571079 1.00 TK1 (0.67) TK1BLMMEN1ALDH1A1LMNA
Buciclovir SCHEMBL571385 0.95 HPRT1 (0.67) TK1BLMMEN1ALDH1A1LMNA
SCHEMBL9663121 0.93 TK1 (0.72) TK1BLMMEN1ALDH1A1LMNA
Penciclovir SCHEMBL3495 0.90 TK1 (0.70) TK1BLMMEN1ALDH1A1LMNA
Penciclovir SCHEMBL10414021 0.89 TK1 (0.69) TK1BLMMEN1ALDH1A1LMNA
Penciclovir SCHEMBL7192792 0.89 TK1 (0.69) TK1BLMMEN1ALDH1A1LMNA
Penciclovir SCHEMBL583037 0.89 TK1 (0.69) TK1BLMMEN1ALDH1A1LMNA
SCHEMBL7173165 0.88 TK1 (0.68) TK1BLMMEN1ALDH1A1LMNA
Buciclovir SCHEMBL11218917 0.88 TK1 (0.56) TK1BLMMEN1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 600 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2024-05-02 US claimed
EP-4045504-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS Ai-biopharma (FR) 2022-08-24 EP claimed
CN-114901657-A Antiviral and liver-targeting drugs 人工智能生物制药公司 2022-08-12 CN claimed
WO-2021074443-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2021-04-22 WO claimed
US-20210094954-A1 PREPARATION METHODS AND APPLICATIONS OF 3,5-DISUBSTITUTED METHYLPYRAZOLO[1,5-A]PYRIMIDINE-7-HYDROXYLIC SALTS XU LIFENG (US) 2021-04-01 US claimed
CN-108912055-B Method for synthesizing antiviral drug cidofovir intermediate and bucyclovir intermediate 河南师范大学 2020-06-30 CN claimed
CN-108912055-A A method of synthesis antiviral agent cidofovir and Buciclovir 河南师范大学 2018-11-30 CN claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
EP-2846788-A1 USE OF COMPOUNDS FOR THE TREATMENT OF PAIN Akron Molecules AG (AT) 2015-03-18 EP claimed
EP-0577725-A4 TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES UNIV FLORIDA (US) 1996-04-17 EP claimed
WO-1994026273-A1 ACYCLOVIR DERIVATIVES FOR TOPICAL USE HOSTETLER KARL Y (US) 1994-11-24 WO claimed
EP-0577725-A1 TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES UNIVERSITY OF FLORIDA (US) 1994-01-12 EP claimed
EP-0559744-A1 COMBINATIONS OF VANILLOID COMPOUNDS AND NUCLEOSIDE ANTIVIRAL COMPOUNDS FOR TREATMENT OF HERPES INFECTIONS THE PROCTER & GAMBLE COMPANY (US) 1993-09-15 EP claimed
EP-0539493-A4 TARGETED DRUG DELIVERY VIA PHOSPHONATE DERIVATIVES 1993-06-02 EP claimed
EP-0539493-A1 TARGETED DRUG DELIVERY VIA PHOSPHONATE DERIVATIVES. BODOR NICHOLAS S (US) 1993-05-05 EP claimed
WO-1992017185-A1 TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES UNIVERSITY OF FLORIDA (US) 1992-10-15 WO claimed
WO-1992009287-A1 COMBINATIONS OF VANILLOID COMPOUNDS AND NUCLEOSIDE ANTIVIRAL COMPOUNDS FOR TREATMENT OF HERPES INFECTIONS THE PROCTER & GAMBLE COMPANY (US) 1992-06-11 WO claimed
WO-1992000988-A1 TARGETED DRUG DELIVERY VIA PHOSPHONATE DERIVATIVES BODOR NICHOLAS S (US) 1992-01-23 WO claimed
US-4495190-A VIRICIDES; ANTITUMOR AND ANTICARCINOGENIC AGENTS ASTRA LAKEMEDEL AKTIEBOLAG (SE) 1985-01-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS HAVCR2, NR1H4, NR1H3 TK1 98/4885BLM 4147/4885MEN1 3514/4885
US-20210094954-A1 PREPARATION METHODS AND APPLICATIONS OF 3,5-DISUBSTITUTED METHYLPYRAZOLO[1,5-A]PYRIMIDINE-7-HYDROXYLIC SALTS DHPS, NUDT1, DPYD TK1 40/4885BLM 3605/4885MEN1 522/4885
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS SLC10A1, HAVCR2, HDGF TK1 37/4885BLM 3381/4885MEN1 3496/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.