Sugi Predict

Sugi Predict / Compounds / Phesa

Phesa

Phesa

SCHEMBL3499221

Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@@H](N)Cc2ccccc2)C(O)C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SARS1 P49591 1/20 0.80
▸ LARS1 Q9P2J5 2/20 0.76
▸ HARS1 P12081 1/20 0.74
▸ TARS1 P26639 2/20 0.74
▸ MARS1 P56192 1/20 0.73
▸ IARS1 P41252 1/20 0.71
▸ RARS1 P54136 1/20 0.70
▸ TRPM2 O94759 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phesa SCHEMBL3499217 1.00 SARS1 (0.80) SARS1LARS1HARS1TARS1MARS1
SCHEMBL4321355 0.93 SARS1 (0.79) SARS1LARS1HARS1TARS1MARS1
SCHEMBL30270578 0.89 SARS1 (0.85) SARS1LARS1HARS1TARS1MARS1
SCHEMBL21068060 0.89 SARS1 (0.87) SARS1LARS1HARS1TARS1MARS1
SCHEMBL3187665 0.89 SARS1 (0.87) SARS1LARS1HARS1TARS1MARS1
SCHEMBL3187637 0.89 SARS1 (0.87) SARS1LARS1HARS1TARS1MARS1
SCHEMBL4313369 0.89 SARS1 (1.00) SARS1LARS1HARS1TARS1MARS1
SCHEMBL21067959 0.89 SARS1 (1.00) SARS1LARS1HARS1TARS1MARS1
SCHEMBL3500697 0.88 SARS1 (0.82) SARS1LARS1HARS1TARS1MARS1
SCHEMBL178823 0.87 SARS1 (0.85) SARS1LARS1HARS1TARS1MARS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8778631-B2 Mono charging system for selectively introducing non-native amino acids into proteins using an in vitro protein synthesis system SUTRO BIOPHARMA, INC. (US) 2014-07-15 — — US disclosed
EP-2376647-B1 MONO CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO PROTEIN SYNTHESIS SYSTEM SUTRO BIOPHARMA INC (US) 2014-03-05 — — EP disclosed
US-20100184135-A1 MONO CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO PROTEIN SYNTHESIS SYSTEM SUTRO BIOPHARMA, INC. (US) 2010-07-22 — — US disclosed
US-20100184134-A1 DUAL CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO SYNTHESIS METHOD SUTRO BIOPHARMA, INC. (US) 2010-07-22 — — US disclosed