SCHEMBL3499679

SCHEMBL3499679

O=C(O)Cc1ccc(NCc2ccc(F)cc2)cc1

nearest known ligand 0.69

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 9/20 0.69
P4HTM Q9NXG6 1/20 0.59
RAB9A P51151 2/20 0.55
GFER P55789 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
GAA P10253 2/20 0.54
PPARA Q07869 3/20 0.54
STING1 Q86WV6 1/20 0.54
FFAR4 Q5NUL3 2/20 0.53
ALDH1A1 P00352 1/20 0.53
KDM4E B2RXH2 1/20 0.51
MAPT P10636 1/20 0.51
ALOX15 P16050 1/20 0.51
ALOX12 P18054 1/20 0.51
HTT P42858 1/20 0.50
LMNA P02545 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5447986 0.86 FFAR1 (0.84) FFAR1RAB9AGFERSMN1; SMN2GAA
SCHEMBL11253749 0.85 GAA (0.57) FFAR1P4HTMRAB9AGFERSMN1; SMN2
SCHEMBL5455400 0.84 GAA (0.59) FFAR1RAB9ASMN1; SMN2GAAALDH1A1
SCHEMBL11461945 0.83 FFAR1 (0.77) FFAR1P4HTMFFAR4
SCHEMBL10055033 0.83 LMNA (0.61) P4HTMGFERSMN1; SMN2GAAALDH1A1
SCHEMBL104746 0.83 CA2 (0.62) FFAR1RAB9AGAAALDH1A1KDM4E
SCHEMBL6419238 0.83 LMNA (0.61) P4HTMGFERSMN1; SMN2GAAALDH1A1
SCHEMBL11232512 0.83 FFAR1 (0.71) FFAR1RAB9AGFERSMN1; SMN2FFAR4
SCHEMBL20641771 0.83 P4HTM (0.59) FFAR1P4HTMRAB9AGFERSMN1; SMN2
SCHEMBL1663181 0.83 PPARA (0.64) P4HTMGFERSMN1; SMN2GAAPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-05-27 US disclosed
EP-1849465-A1 AGENT FOR CONTROLLING FUNCTION OF GPR34 RECEPTOR Takeda Pharmaceutical Company Limited (JP) 2007-10-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function GPR34, GPR4, GPR6 FFAR1 33/4885P4HTM 1492/4885RAB9A 2269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.