Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.50 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MTOR | P42345 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10987303 | 0.87 | SLC6A4 (0.56) | MEN1KMT2ALMNANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10987609 | 0.86 | SLC6A4 (0.57) | MEN1KMT2ALMNANPC1RAB9A | |
| Oxalic Acid SCHEMBL4054 | 0.84 | SLC6A4 (0.50) | MEN1KMT2ASLC6A4KDM4EHRH3 | |
| SCHEMBL5143084 | 0.77 | SLC6A2 (0.50) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3501 | 0.77 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2HPGDGCGR | |
| Citric Acid SCHEMBL3868 | 0.77 | MMP1 (0.40) | MEN1KMT2ANPC1RAB9ACYP2D6 | |
| SCHEMBL10989204 | 0.75 | SLC6A4 (0.46) | MEN1KMT2ALMNANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3937 | 0.75 | SLC6A4 (0.52) | MEN1KMT2ALMNACYP3A4SLC6A2 | |
| Fluoxetine SCHEMBL8722258 | 0.74 | SLC6A4 (0.88) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL5079349 | 0.74 | SLC6A4 (0.51) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |