Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.35 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055 | 0.83 | NPC1 (0.38) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| Oxalic Acid SCHEMBL3500 | 0.77 | MEN1 (0.50) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL4739538 | 0.73 | SLC6A9 (0.52) | SMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL3730 | 0.73 | MEN1 (0.44) | RAB9AADAMTS4ADAMTS5PPARGPPARA | |
| SCHEMBL3555 | 0.72 | OPRM1 (0.43) | SMN1; SMN2NPC1HPGDRAB9APPARG | |
| Oxalic Acid SCHEMBL4054 | 0.72 | SLC6A4 (0.50) | SLC6A5 | |
| SCHEMBL4739366 | 0.72 | SLC6A9 (0.53) | SMN1; SMN2NPC1HPGDRAB9APPARG | |
| SCHEMBL5312894 | 0.72 | EPHX2 (0.36) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL10359727 | 0.72 | SLC7A5 (0.52) | SMN1; SMN2NPC1HPGDRAB9APPARG | |
| SCHEMBL5143084 | 0.71 | SLC6A2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |