Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3937 | 0.92 | SLC6A4 (0.52) | SLC6A4HRH3SLC6A9MEN1KMT2A | |
| SCHEMBL10989251 | 0.87 | SLC6A4 (0.56) | SLC6A4HRH3SLC6A9KDM4EMEN1 | |
| Oxalic Acid SCHEMBL3500 | 0.84 | MEN1 (0.50) | SLC6A4HRH3KDM4EMEN1MITF | |
| SCHEMBL5143084 | 0.77 | SLC6A2 (0.50) | SLC6A4MEN1MITFKMT2A | |
| SCHEMBL4055 | 0.77 | NPC1 (0.38) | SLC6A4SLC6A9 | |
| SCHEMBL10996291 | 0.75 | SLC6A9 (0.44) | SLC6A4HRH3SLC6A9KDM4EUTS2R | |
| Oxalic Acid SCHEMBL7317614 | 0.74 | SLC6A4 (0.88) | SLC6A4HRH3SLC6A9KDM4EMEN1 | |
| Oxalic Acid SCHEMBL4740319 | 0.73 | SLC6A4 (0.72) | SLC6A4HRH3SLC6A9SLC6A5UTS2R | |
| SCHEMBL10989062 | 0.73 | SLC6A4 (0.44) | SLC6A4HRH3KDM4EMEN1KMT2A | |
| SCHEMBL10984411 | 0.73 | SLC6A4 (0.43) | SLC6A4HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |