Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.75 |
| ▸ | POLB | P06746 | 5/20 | 0.75 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.57 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.57 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.55 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.55 |
| ▸ | ECE1 | P42892 | 1/20 | 0.55 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3500390 | 1.00 | MAPT (0.75) | MAPTPOLBTRPM5LMNASMN1; SMN2 | |
| SCHEMBL15275439 | 0.83 | MAPT (0.67) | MAPTPOLBLMNASMN1; SMN2HTT | |
| SCHEMBL3633031 | 0.82 | TRPM5 (0.62) | MAPTPOLBTRPM5LMNASMN1; SMN2 | |
| SCHEMBL3633028 | 0.82 | TRPM5 (0.62) | MAPTPOLBTRPM5LMNASMN1; SMN2 | |
| SCHEMBL31612234 | 0.82 | TRPM5 (1.00) | MAPTPOLBTRPM5SMN1; SMN2HTT | |
| SCHEMBL3861202 | 0.82 | TRPM5 (1.00) | MAPTPOLBTRPM5SMN1; SMN2HTT | |
| SCHEMBL3861198 | 0.82 | TRPM5 (1.00) | MAPTPOLBTRPM5SMN1; SMN2HTT | |
| SCHEMBL14125518 | 0.81 | MAPT (0.59) | MAPTPOLBTRPM5LMNASMN1; SMN2 | |
| SCHEMBL14125517 | 0.81 | MAPT (0.59) | MAPTPOLBTRPM5LMNASMN1; SMN2 | |
| SCHEMBL3720562 | 0.80 | ERCC1 (0.58) | MAPTPOLBSMN1; SMN2HTTERCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609649-B2 | Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases | BRANDEIS UNIVERSITY (US) | 2013-12-17 | — | — | US | claimed |
| US-20100152125-A1 | Compositions And Methods For The Diagnosis, Treatment, And Prevention Of Amyotrophic Lateral Sclerosis And Related Neurological Diseases | BRANDEIS UNIVERSITY (US) | 2010-06-17 | — | — | US | claimed |
| EP-2139460-A1 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED NEUROLOGICAL DISEASES | Brandeis University (US) | 2010-01-06 | — | — | EP | claimed |
| WO-2008116092-A1 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED NEUROLOGICAL DISEASES | BRANDEIS UNIVERSITY (US) | 2008-09-25 | — | — | WO | claimed |
| EP-3085367-A2 | COMPOSITIONS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED | Brandeis University (US) | 2016-10-26 | — | — | EP | disclosed |
| US-8609649-B2 | Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases | BRANDEIS UNIVERSITY (US) | 2013-12-17 | — | — | US | disclosed |
| US-20100152125-A1 | Compositions And Methods For The Diagnosis, Treatment, And Prevention Of Amyotrophic Lateral Sclerosis And Related Neurological Diseases | BRANDEIS UNIVERSITY (US) | 2010-06-17 | — | — | US | disclosed |
| EP-2139460-A1 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED NEUROLOGICAL DISEASES | Brandeis University (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116092-A1 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED NEUROLOGICAL DISEASES | BRANDEIS UNIVERSITY (US) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152125-A1 | Compositions And Methods For The Diagnosis, Treatment, And Prevention Of Amyotrophic Lateral Sclerosis And Related Neurological Diseases | SOD1, SOD3, AGER | MAPT 197/4885POLB 750/4885TRPM5 2334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.