Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9004267 | 0.72 | NR1H2 (0.47) | MEN1KMT2ABRD4AURKAAURKB | |
| SCHEMBL9004285 | 0.69 | CASP3 (0.56) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL6555948 | 0.68 | RAB9A (0.85) | MAPTLMNAMEN1KMT2AAURKA | |
| SCHEMBL7606680 | 0.68 | RAB9A (0.85) | MAPTLMNAMEN1KMT2AAURKA | |
| SCHEMBL10098929 | 0.67 | ALDH1A1 (0.62) | MAPTLMNAMEN1KMT2ARAB9A | |
| SCHEMBL9100124 | 0.66 | NR1H2 (0.40) | MAPTLMNAMEN1KMT2ABRD4 | |
| SCHEMBL15397061 | 0.66 | ALDH1A1 (0.56) | MAPTLMNAMEN1KMT2ARAB9A | |
| SCHEMBL14363224 | 0.66 | MEN1 (0.73) | MAPTLMNAMEN1KMT2AAURKA | |
| SCHEMBL25666657 | 0.66 | CSNK2A2 (0.39) | LMNAMEN1KMT2ACA2 | |
| SCHEMBL17166043 | 0.65 | POLB (0.65) | MAPTLMNAMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100146-A1 | AWAT-related methods and articles | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2006-05-11 | — | — | US | claimed |
| US-20100152277-A1 | DIACYLGLYCEROL ACYLTRANSFERASE ASSAY | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-06-17 | — | — | US | disclosed |
| EP-1831393-A1 | DIACYLGLYCEROL ACYLTRANSFERASE ASSAY | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067071-A1 | DIACYLGLYCEROL ACYLTRANSFERASE ASSAY | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |
| US-20060100146-A1 | AWAT-related methods and articles | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2006-05-11 | — | — | US | disclosed |
| US-6607893-B2 | Measuring diacylglycerol acetyltransferase activity; obtain enzmatic substrate, expose to microsomes, terminate reaction, monitor triglyceride generation | WARNER-LAMBERT COMPANY | 2003-08-19 | — | — | US | disclosed |
| US-20020127627-A1 | Diacylglycerol acyltransferase (DGAT) assay | RAMHARACK RANDY RANJEE (US) | 2002-09-12 | — | — | US | disclosed |
| EP-1219716-A2 | Diacylglycerol acyltransferase (DGAT) assay | WARNER-LAMBERT COMPANY (US) | 2002-07-03 | — | — | EP | disclosed |