Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.52 |
| ▸ | RXRA | P19793 | 9/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | VDR | P11473 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801838 | 0.89 | ALDH1A1 (0.52) | RXRANPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL3499100 | 0.88 | NR1H2 (0.65) | NR1H2RXRANR1H3ALOX5 | |
| SCHEMBL4417759 | 0.84 | ALDH1A1 (0.48) | RXRANPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL4430140 | 0.84 | NPC1 (0.52) | RXRANPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL1679004 | 0.80 | NR1H2 (0.82) | NR1H2RXRANR1H3NPC1ALDH1A1 | |
| SCHEMBL3995720 | 0.79 | TSHR (0.50) | NR1H2RXRANR1H3ALDH1A1KMT2A | |
| SCHEMBL6295627 | 0.78 | MAOB (0.61) | RXRANPC1ALDH1A1RAB9AESR1 | |
| SCHEMBL3500927 | 0.78 | MRGPRX4 (0.59) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3995767 | 0.77 | NAMPT (0.47) | NR1H2RXRANR1H3NPC1ALDH1A1 | |
| SCHEMBL4354325 | 0.77 | MAOB (0.62) | RXRANPC1ALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130737-A1 | Regulating Agent of GPR34 Receptor Function | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
| EP-1849465-A1 | AGENT FOR CONTROLLING FUNCTION OF GPR34 RECEPTOR | Takeda Pharmaceutical Company Limited (JP) | 2007-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130737-A1 | Regulating Agent of GPR34 Receptor Function | GPR34, GPR4, GPR6 | NR1H2 75/4885RXRA 275/4885NR1H3 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.