Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752790 | 0.77 | ILK (0.32) | — | |
| SCHEMBL5578040 | 0.76 | DYRK1A (0.32) | — | |
| SCHEMBL3500620 | 0.75 | RPS6KA3 (0.41) | ALDH1A1HPGD | |
| SCHEMBL2678404 | 0.69 | ALDH1A1 (0.38) | ALDH1A1HPGD | |
| SCHEMBL3501102 | 0.69 | CYP1A2 (0.43) | ALDH1A1HPGD | |
| SCHEMBL16751984 | 0.68 | ALDH1A1 (0.42) | ALDH1A1HPGD | |
| SCHEMBL13256288 | 0.68 | NPC1 (0.52) | ALDH1A1HPGD | |
| SCHEMBL3501617 | 0.65 | GRM2 (0.38) | ALDH1A1HPGD | |
| SCHEMBL3498258 | 0.65 | LRRK2 (0.40) | ALDH1A1 | |
| SCHEMBL9108114 | 0.65 | GAA (0.41) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179190-A1 | BICYCLIC PYRAZOLO PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2010-07-15 | — | — | US | disclosed |
| US-7473783-B2 | Bicyclic pyrazolo protein kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2009-01-06 | — | — | US | disclosed |
| US-20050176786-A1 | Bicyclic pyrazolo protein kinase modulators | STRUCTURAL GENOMIX (US) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179190-A1 | BICYCLIC PYRAZOLO PROTEIN KINASE MODULATORS | MAP3K20, MAP4K2, MAP4K3 | ALDH1A1 4737/4885HPGD 2895/4885 |
| US-20050176786-A1 | Bicyclic pyrazolo protein kinase modulators | MAP3K20, MAP4K2, MAP4K3 | ALDH1A1 4737/4885HPGD 2895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.