Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3501792 | 0.77 | KDM4E (0.71) | KDM4EPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL3501797 | 0.77 | KDM4E (0.71) | KDM4EPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL26450025 | 0.71 | MAPT (0.64) | KDM4EPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL570055 | 0.69 | MAPT (1.00) | KDM4EPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL17742689 | 0.68 | MAPT (0.75) | KDM4EPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL18555711 | 0.66 | MAPT (0.75) | KDM4EPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL16841241 | 0.66 | ALDH1A1 (0.65) | KDM4EPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL17773163 | 0.65 | MAPT (0.69) | KDM4EPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL1430060 | 0.65 | POLB (0.64) | KDM4EPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL569756 | 0.64 | DRD3 (0.54) | KDM4EPOLBALDH1A1RECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609649-B2 | Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases | BRANDEIS UNIVERSITY (US) | 2013-12-17 | — | — | US | claimed |
| US-20100152125-A1 | Compositions And Methods For The Diagnosis, Treatment, And Prevention Of Amyotrophic Lateral Sclerosis And Related Neurological Diseases | BRANDEIS UNIVERSITY (US) | 2010-06-17 | — | — | US | claimed |
| EP-3085367-A2 | COMPOSITIONS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED | Brandeis University (US) | 2016-10-26 | — | — | EP | disclosed |
| US-8609649-B2 | Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases | BRANDEIS UNIVERSITY (US) | 2013-12-17 | — | — | US | disclosed |
| US-20100152125-A1 | Compositions And Methods For The Diagnosis, Treatment, And Prevention Of Amyotrophic Lateral Sclerosis And Related Neurological Diseases | BRANDEIS UNIVERSITY (US) | 2010-06-17 | — | — | US | disclosed |
| EP-2139460-A1 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED NEUROLOGICAL DISEASES | Brandeis University (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116092-A1 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED NEUROLOGICAL DISEASES | BRANDEIS UNIVERSITY (US) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152125-A1 | Compositions And Methods For The Diagnosis, Treatment, And Prevention Of Amyotrophic Lateral Sclerosis And Related Neurological Diseases | SOD1, SOD3, AGER | KDM4E 2386/4885POLB 750/4885ALDH1A1 856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.